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毒作用模式和有害结局通路 被引量:8

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摘要 随着机制毒理学研究的深入和危险评定的需要,已发展了作用模式(Mode of Action,MOA)的概念,WHO/IPCS(2007)提出致癌和非致癌MOA的指南。
作者 周宗灿
机构地区 北京大学医学部
出处 《毒理学杂志》 CAS CSCD 北大核心 2014年第1期1-2,共2页 Journal of Toxicology
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参考文献2

  • 1WHO/IPCS. Document No. 4. Part 1 : IPCS Cancer Mode of Action for Humans and Case-Studies. Part 2: IPCS Framework for Analysing the Relevance of a non Cancer Mode of Action for Humans. 2007.
  • 2OECD. Guidance Document on Developing and Assessment Adverse Outcome Pathways, 2013.

同被引文献81

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  • 2曹梦苒,华海清,秦叔逵.神经节苷脂预防奥沙利铂周围神经毒性的研究[J].肿瘤防治研究,2014,41(4):387-390. 被引量:21
  • 3杨志芳,毛飞,黄正明.肝纤维化的形成机制及治疗的研究进展[J].解放军药学学报,2006,22(2):129-132. 被引量:13
  • 4Zedan AH, Hansen TF, Svenningsen AF, et al. Oxaliplatin-induced neuropathy in coloreetal cancer: many questions with few answers [ J ]. Clin Colorectal Cancer, 2014, 13(2) : 73-80.
  • 5Zaanan A, Williet N, Hebbar M, et al. Gemcitabine plus oxaliplatin in advanced hepatocellular carcinoma: a large multicenter AGEO study [J]. J Hepatol, 2013, 58 ( 1 ) : 81-88.
  • 6Velasco It, Bruna J. Oxaliplatin Neurotoxicity [ J]. Curr Colorectal Cancer Rep, 2014, 10 (3) : 303-312.
  • 7Montagnani F, Turrisi G, Marinozzi C, et al. Effectiveness and safety of oxaliplatin compared to cisplatin for advanced, unresectable gastric cancer: a systematic review and meta-analysis [ J]. Gastric Cancer, 201 I, 14 ( 1 ) : 50-55.
  • 8Stein A, Arnold D. Oxaliplatin: a review of approved uses [ J]. Expert Opin Pharmaeother, 2012, 13 ( 1 ) : 125-137.
  • 9Argyriou AA, Cavaletti G, Briani C, et al. Clinical pattern and associations of oxaliplatin acute neurotoxicity: a prospective study in 170 patients with colorectal cancer [J]. Cancer, 2013, 119(2): 438-444.
  • 10Sereno M, Guti6rrez-Guti6rrez G, G6mez-Raposo C, et al. Oxaliplatin indueed-neuropathy in digestive tumors [ J ]. Crit Rev Oncol Hematol, 2014, 89( 1 ) : 166-178.

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