青娥方对绝经后骨质疏松伴有骨痛患者血清IGF-1、IL-6以及TNF-α水平的影响

The Effect of Qing'e Pill on The Serum Levels of IGF-1、IL-6 and TNF-αin Patients with Postmenopausal Osteoporosis Accompanied with Pain on Bone

目的:观察古方青娥丸治疗绝经后骨质疏松症患者腰背疼痛的近期疗效,以及对患者血清中IGF-1、IL-6以及TNF-α水平的影响。方法:60例绝经后骨质疏松患者随机分为,青娥丸治疗组(治疗组)和对照组。治疗组每次口服青娥丸1丸,每日3次,同时口服钙尔奇D 600mg,每日1次。对照组每日口服钙尔奇D 600mg,两组均治疗3个月。重点观察患者腰背疼痛疗效;并于治疗前后取空腹血清,Elisa法检测血清中IGF-1、IL-6以及TNF-α的水平。结果:治疗组疼痛症状明显好转,且明显优于对组组(P<0.05);血清中IL-6以及TNF-α的水平明显降低,IGF-1水平升高,对照组不显,组间疗后比较差异有统计学意义(P<0.001)。结论:青娥方治疗绝经后骨质疏松所致的腰背疼痛效果显著,且安全,其机制可能与降低体内IL-6、TNF-α水平,增加IGF-1水平,抑制绝经后代谢性骨丢失,促进骨形成有关。

Objective：To evaluate the effect and safety of Qing＇e Pill in treating postmenopausal osteoporosis and the change-ment of the serum levels of IGF-1, IL-6 and TNF-α . Methods：Sixty patients with postmenopausal osteoporosis were ran-domly divided into two groups. The treatment group was treated with Qing＇e Pill, one Pill once and 3 times a day plus Cal-trate 600rag, once a day. The control group was treated with Caltrate 600mg only. Effect was evaluated by the symptoms. IGF-1, IL-6 and TNF-α levels in serum were tested by ELISA three months later. Results：Symptoms were obviously im-proved in the treatment group （P〈0.05）. Inflammatory factors including IL-6 and TNF-α in serum were decreased except the IGF-1, there was statistical difference between the two groups after treatment （P〈0. 001）. Conclusion： Qing＇e Pill is effective and safe for the treatment of Postmenopausal osteoporosis with pain. Qing＇e Pill may treat the Postmenopausal os-teoporosis via decreasing the levels of IL-6 and TNF-α increasing the level of IGF-1.