河南林州石村居民反流性食管炎发病特征和食管癌家族史调查

Characterization of reflux esophagitis(RE)incidence and family history esophageal cancer from the residents in Shicun village from Linzhou,Henan

目的调查食管癌高发区河南林州市石村居民反流性食管炎(reflux esophagitis,RE)和食管癌家族史流行特征,加深对食管癌发病机制的了解。方法采用问卷调查表,包括一般情况、上消化道疾病史以及食管癌家族史调查三项主要内容,对石村334户508人进行逐一调查。采用Excel和SPSS 18.0进行数据分析。结果 RE评分>12分者有28人,占总调查人数的5.5%,其中男性8人(28.6%),女性20人(71.4%)。在调查的334户中,家族性食管癌52户(15.57%)。结论河南省食管癌高发区食管反流发生率明显低于西方国家,而食管癌家族聚集现象十分常见,提示中国食管癌的发病模式不同于西方。

Objective To characterize the prevalence of reflux esophagitis （RE） and esophageal cancer family history on the residents in the Shicun village from Linzhou, Henan the high incidence area for esophageal cancer. To further provide the basic data for the pathogenesis research of EC. Methods The questionnaire was performed on 508 subjects from 334 households in Shicun village. The survey contents included the general information, upper gastrointestinal disease history and family history of esophageal cancer and so on. Excel and SPSS 18.0 software were applied to data analysis. Results There were 28 people with a score of RE for more than 12 points were 28 people, accounting for 5.5% of those surveyed, among them, 8 （28.6%） people were male, 20 （71.4%） people were females. The fifty two （15.57%） family had esophageal cancer history in the survey of 334 families. Conclusion The reflux esophagitis in Henan high-incidence area for esophageal cancer was significantly lower than in Western countries, and familial aggregation of esophageal cancer is very common, suggesting that the model of esophageal carcinogenesis may be different between China and Western countries.