老年男性血清抵抗素水平与高血压的关系

Relation between serum resistin level and hypertension in elderly males

目的探讨老年男性血清抵抗素水平与高血压的关系。方法选择老年男性843例,根据血压情况分为高血压组(556例)和非高血压组(287例)。检测血清抵抗素、胱抑素C、C反应蛋白、N末端B型钠尿肽前体(NT-proBNP)、血脂、血糖和肌酐,并估算肾小球滤过率(eGFR)。分析受试者各项指标,并进行多元线性回归分析。结果高血压组与非高血压组血清抵抗素水平比较,差异无统计学意义(P>0.05),但随着四分位区间抵抗素水平的升高,高血压发生率明显升高,差异有统计学意义(P<0.05);Spearman相关分析显示,抵抗素与收缩压、年龄、ln肌酐、胱抑素C、lnTG、lnC反应蛋白和lnNT-proBNP呈正相关(P<0.05);与舒张压、eGFR、TC、LDL-C和lnHDL-C呈负相关(P<0.05);多元线性回归分析显示,校正年龄、病史及药物治疗后,收缩压和舒张压与血清抵抗素水平无相关性;二元logistic回归分析显示,抵抗素水平不是高血压的危险因素。结论随着抵抗素水平的升高,高血压发生率有升高趋势,提示抵抗素可能在高血压的发生和发展过程中起着一定作用。

Objective To study the relation between serum resistin level and hypertension in elder- ly males. Methods Eight hundred and forty-three elderly males were divided into hypertension group （n= 556） and non-hypertension group （n=287）. Their serum levels of resistin, cystatin-C, CRP, NT-proBNP, TC, TG, LDL-C, HDL-C, blood glucose, Cr and eGFR were measured and ana- lyzed by correlation analysis and multiple linear regression analysis, respectively. Results No sig- nificant difference was found in the serum resistin level between hypertension group and non-hy- pertension group （P〈0.05）. The incidence of hypertension increased with the serum resistin level （P〈0.05）. Spearman correlation analysis showed that serum resistin level was positively related with age, SBP, lnCr, cystatin-C, lnTG, lnCRP, lnNT-proBNP （P〈0. 05）, and negativelyrelated with eGFR,DBP,TC,LDL-C,InHDL-C （P〈0. 05）. Multiple linear regression analysis displayed that SBP and DBP were not related with serum resistin level when adjusted for age, gender and drug use. Logistic regression analysis revealed that serum resistin level was not the risk factor for hypertension. Conclusion The incidence of hypertension increases with the serum resistin level, indicating that serum resistin level may play a certain role in the occurrence and progress of hy- pertension.