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不同剂量瑞舒伐他汀对不稳定性心绞痛患者介入治疗围术期心肌损伤及炎性因子的影响 被引量:31

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摘要 目的探讨不同剂量瑞舒伐他汀对不稳定性心绞痛患者PCI围术期心肌损伤及炎性因子的影响。方法选取94例拟行择期PCI的不稳定性心绞痛患者,分为5mg瑞舒伐他汀组(5mg组)31例、10mg瑞舒伐他汀组(10mg组)30例、20mg瑞舒伐他汀组(20mg组)33例。3组在常规药物基础上,于术前2d口服瑞舒伐他汀5、10、20mg/d,PCI术后继续口服5mg/d。分别于PCI术前(入院时未服用他汀类药物)、术后18-24h检测肌钙蛋白Ⅰ、肌酸激酶同工酶及高敏C反应蛋白、TNF-α、干扰素-γ、白细胞介素(IL)6、IL-10的表达。结果PCI术后18~24h,5mg组、10mg组和20mg组患者肌钙蛋白Ⅰ高于正常高值的发生率,分别为(45.6±9.8)%、(37.8±7.6)%和(28.6±5.4)%,与5mg组比较,20mg组发生率明显降低(P〈0.05);肌酸激酶同工酶高于正常高值的发生率,分别为(19.5±5.3)%、(15.7±3.4)%和(6.7±2.6)%,与5mg组比较,20mg组发生率明显降低,差异有统计学意义(P〈0.05);3组PCI术前血清高敏C反应蛋白、TNF-α、干扰素-γ、IL-6和IL-10水平比较,差异无统计学意义(P〉0.05)。与PCI术前比较,PCI术后5mg组和10mg组高敏C反应蛋白明显升高,10mg组和20mg组IL-10明显升高,差异有统计学意义(P〈0.05)。与5mg组比较,20mg组以上各项炎性指标水平(除外IL-10升高)明显降低,差异有统计学意义(P〈0.05)。结论PCI术前给予大剂量的瑞舒伐他汀可以更有效降低炎性因子的水平及术后心肌损伤的发生率。
出处 《中华老年心脑血管病杂志》 CAS 北大核心 2014年第4期431-433,共3页 Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
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