氟比洛芬酯联合地佐辛对心脏搭桥术后镇痛效果对比研究

Comparative on the Analgesic Effect of Flurbiprofen Joint Dezocine in Cardiac Bypass Surgery

目的:评价氟比洛芬酯联合地佐辛用于心脏搭桥术后的镇痛效果。方法:选取2011年5月-2013年6月在本院心外科择期行心脏搭桥术的患者86例,按随机数字法分为联合用药组和单一用药组,两组患者麻醉诱导和麻醉维持方法相同。联合用药组:氟比洛芬酯+地佐辛术后自控静脉镇痛;单一用药组:芬太尼术后自控静脉镇痛。术后评价两组患者镇痛效果和镇静效果,并记录不良反应情况。结果:联合用药组不同时点的疼痛评分均低于单一用药组,差异均有统计学意义(P<0.05);联合用药组不同时点镇静评级与单一用药组比较,差异均无统计学意义(P>0.05);联合用药组总不良反应率为11.6%,显著低于单一用药组的48.8%,差异有统计学意义(P<0.05)。结论:氟比洛芬酯联合地佐辛用于心脏搭桥术后自控静脉镇痛,具有较好的镇痛和镇静效果,能够显著降低不良反应发生率,值得临床推广。

Objective：To investigate the analgesic effect of flurbiprofen joint dezocine in cardiac bypass surgery. Method：86 patients in cardiac surgery elective for heart bypass surgery were selected from May 2011 to June 2013 in our hospital. They were randomly divided into combination therapy group and monotherapy group according to the admission number parity. Anesthesia induction and maintenance of anesthesia on patients of two groups were in the same way. In the combination therapy group,flurbiprofen ＋ dezocine were used in controlled intravenous analgesia after surgery. In the monotherapy group,fentanyl was used in controlled intravenous analgesia. The effects of analgesia and sedation postoperative were evaluated in the two groups. And the adverse reactions were recorded. Result：The pain scores at different time points of the combination therapy group were lower than the monotherapy group,the differences were statistically significant（P＆lt;0.05）. The differences of sedation ratings at different time points between the combination therapy group and monotherapy group were not statistically significant（P＆gt;0.05）. The total adverse reaction rate of the combination therapy group was 11.6%,which was significantly lower than 48.8%of the monotherapy group,the difference was statistically significant（P＆lt;0.05）. Conclusion：In cardiac bypass surgery,flurbiprofen joint dezocine in controlled analgesia has better effects of analgesic and sedative. It can significantly reduce the incidence rate of adverse reactions. It is worthy of clinical use.