急性胰腺炎患者血清D-二聚体及炎性因子的检测及意义

Clinical Value of Serum D-Dimer and Inflammatory Cytokines in Patients with Acute Pancreatitis

目的探讨急性胰腺炎(AP)患者血液D-二聚体及炎性因子的变化情况及其临床意义。方法急性胰腺炎患者107例,其中44例为重症急性胰腺炎(SAP)患者,63例为轻症急性胰腺炎(MAP)患者,检测其治疗前后血清D-二聚体、白细胞介素-6(IL-6)、C-反应蛋白(CRP)水平,并与121例健康对照组比较。结果与健康对照组比较,SAP组、MAP组的D-二聚体、IL-6和CRP水平均明显升高(P<0.05);SAP组的D-二聚体、IL-6和CRP水平均高于MAP组(P<0.05);107例患者治疗后上述指标水平显著降低(P<0.05)。结论血清D-二聚体、IL-6和CRP水平对AP的诊断及严重程度的预测、临床疗效的评价具有一定价值。

Objective To investigate the changes and clinical value of D-dimer（DD） and inflammatory cytokines in patients with acute pancreatitis（AP）.Methods Among 107 AP patients,there were 44 with severe AP（SAP） and 63 with mild AP（MAP）.The levels of DD,interleukin-6（IL-6）,C-reactive protein（CRP） were detected in 107 AP before and after treatment,which were compared with 121 health controls.Results Compared with the health controls,the levels of DD,IL-6 and CRP in SAP and MAP groups increased significantly （P〈0.05）.The levels of DD,IL-6 and CRP in SAP group were significantly higher than those in MAP group （P〈0.05）.The levels of indexes above decreased significantly after treatment （ P〈0 .05 ） .Conclusion The serum levels of DD ,IL-6 and CRP may be valuable in the diagnosis and prediction of development of acute pancreatitis as well as evaluation of clinical efficacy of acute pancreatitis .