肺癌患者血浆纤维蛋白原、D-二聚体及抗凝血酶Ⅲ水平的变化及临床意义

Changes and Clinical Significance of Plasma Fibrinogen,D-Dimer and Antithrombin Ⅲ Levels in Patients with Lung Cancer

目的观察肺癌患者血浆纤维蛋白原(FIB)、D-二聚体及抗凝血酶Ⅲ(AT-Ⅲ)水平变化并探讨其临床意义。方法肺癌患者73例(观察组),健康志愿者60例(对照组),检测两组血浆FIB、D-二聚体及AT-Ⅲ水平。结果观察组血浆FIB、D-二聚体水平显著高于对照组,而AT-Ⅲ水平显著低于对照组(P均<0.05);Ⅲ、Ⅳ期患者血浆FIB、D-二聚体水平高于Ⅰ、Ⅱ期(P<0.05),而Ⅲ、Ⅳ期患者AT-Ⅲ水平低于Ⅰ、Ⅱ期(P<0.05)。结论检测FIB、D-二聚体以及AT-Ⅲ的水平可作为肺癌进展的辅助诊断指标。

Objective To observe the changes of plasma fibrinogen （ FIB ） , D-dimer and antithrombin Ⅲ（ AT-Ⅲ） in patients with lung cancer ,and to explore their clinical significance .Methods Seventy-three cases of lung cancer（observation group） and 60 healthy volunteers（control group） were enrolled in the study,the plasma FIB,D-dimer and AT-Ⅲlevels were detected in two groups .Results The FIB,D-dimer levels of observation group were significantly higher than those of control group,while the AT-Ⅲlevel was significantly lower than that of control group （all P〈0.05）. The plasma FIB,D-dimer levels of patients in phases Ⅲ,Ⅳwere higher than those of patients in phasesⅠ,Ⅱ（P〈0.05）, while the AT-Ⅲlevel of patients in phases Ⅲ,Ⅳwas lower than that of patients in phasesⅠ,Ⅱ（P〈0.05）.Conclusion The detection of FIB ,D-dimer and AT-Ⅲlevels can be used as the auxiliary indexes for the diagnosis of lung cancer progression .