脑梗死患者幽门螺杆菌感染情况及其对超敏C反应蛋白、血脂代谢的影响

Situation of Helicobacter Pylori Infection in Patients with Cerebral Infarction and Its Effect on High-Sensitivity C-Reactive Protein and Blood Lipid Metabolism

目的观察脑梗死患者幽门螺杆菌(HP)感染情况,探讨其对超敏C反应蛋白(hs-CRP)、血脂代谢的影响。方法应用酶联免疫吸附分析法检测54例脑梗死患者(观察组)及50例体检健康者(对照组)血清HP抗体(HP-IgG),同时检测观察组患者血清甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及载脂蛋白A、B(ApoA、ApoB)及hs-CRP水平。结果观察组HP-IgG阳性率为66.7%(36/54),明显高于对照组的44.0%(22/50)(P<0.05);观察组中HP-IgG阳性患者血清TG、TC、LDL-C、ApoA、ApoB及hs-CRP水平均明显高于HP-IgG阴性患者(P<0.05),而HDL-C明显低于HP-IgG阴性患者(P<0.05)。结论 HP感染与脑梗死的发生有密切关系,且前者可能影响脑梗死患者血脂及hs-CRP代谢。

Objective To observe the situation of helicobacter pylori （ HP） infection in patients with cerebral infarction,and to investigate its effect on high-sensitivity C-reactive protein （ hs-CRP） and blood lipid metabolism. Methods Enzyme linked immunosorbentassay （ ELISA） was used to test the serum HP antibody Ig-G（ HP-IgG） in 54 cases of cerebral infarction（observation goup） and 50 normal volunteers（control group）.At the same time,the serum levels of triglyceride（TG）,total cholesterol（TC）,high density lipoprotein-cholesterol（HDL-C）,low density lipopro-tein-cholesterol（LDL-C）,apolipoprotein A（ApoA）,apolipoprotein B（ApoB） and hs-CRP in the observation group were detected.Results The positive rate of serum HP-IgG in the observation group was 66.7%（36/54）,which was significantly higher than that[44.0%（22/50）]of control group（P〈0.05）.The serum levels of TG,TC,LDL-C, ApoA,ApoB and hs-CRP in HP-IgG （ ＋） cases were significantly higher than those in HP-IgG （ -） cases in the observation group（P〈0.05）,and the serum level of HDL-C in Hp-IgG（＋） cases was significantly lower than that in HP-IgG（-） cases（P〈0.05）.Conclusion HP infection closely associates with cerebral infarction ,it may influence the levels of blood lipid and hs-CRP in patients with cerebral infarction .