期刊文献+

急性冠脉综合征经皮冠状动脉成形术前合用一次大剂量他汀及叶酸对血清炎症指标及促炎指标的影响

下载PDF
导出
摘要 目的探讨急性冠脉综合征经皮冠脉成形术(PCI)前一次大剂量他汀合用叶酸及维生素B6(VB6)对炎症的影响。方法将80例急性冠脉症患者分为观察组和对照组,各40例。观察组给予术前一次阿托伐他汀80 mg,术后40mg/d及叶酸20mg/d、VB6200 mg/d;对照组单使用普通剂量阿托伐他汀20 mg/d。于服药前及PCI术后2 d检测血清高敏C反应蛋白(hsCRP)及同型半胱氨酸(Hcy)。结果 PCI术后,观察组hsCRP及Hcy低于对照组。观察组有1例肝功能异常及2例消化道症状,无横纹肌溶解。结论术前一次大剂量他汀有利于减轻PCI术后炎症反应,且安全;合用叶酸及VB6治疗可以降低同型半胱氨酸,加强疗效。
机构地区 宁波市第二医院
出处 《现代实用医学》 2014年第3期284-285,共2页 Modern Practical Medicine
  • 引文网络
  • 相关文献

参考文献5

  • 1Mascri A. Inflammation in acute coronary syndromes [J]. Haematologica,2001,86 (11 Suppl 12):1-2.
  • 2Biasucci LM, Linzzo G, Funtuzzi G, et al.Increasing Levels of interleukin(IL-2) and IL-6 during the first 2 days of hospitaliza- tion in unstable angina are associate with an increased risk of in hospital coronary events [J].Circulation, 1999,99( 16):2079-2084.
  • 3Sinsh U, Devaraj S, Jialal I, et al.Com- parison effect of atorvastatin (10 mg v 80 mg)on biomarkers of inflammation and oxidative stress in subjects with metabolic syndrome[J].Am J Cardio,2008,102(3): 321-325.
  • 4Astin RC, Lents SR, Werstuck GH. Role of hyperhomoeystine mia in endothelial dysfunction and athemthmmbotic disease[J]. Cell Death Differ,2004,11 (Suppl 1 ):56-64.
  • 5Suhara T, Fukuo K, Yasuda O, et al .Homo- eysteine enhances endothelial apotosis via upregulation of Fas-mediated pathways [J]. Hypertension,2004,43(6):1208-1213.
;
使用帮助 返回顶部