妊娠期肝内胆汁淤积症100例临床分析

Clinical analysis of 100 cases of intrahepatic cholestasis of pregnancy women

目的分析妊娠期肝内胆汁淤积症对孕妇与胎儿的危害,为临床治疗提供依据。方法将我院收治的100例妊娠期肝内胆汁淤积症产妇作为观察组,以同期100例健康妊娠期产妇作为对照组,比较2组产妇的妊娠结局、围生儿预后情况以及相应的生化指标水平。结果观察组羊水污染、胎儿窘迫、剖宫产、早产、产后出血发生率分别为18.00%,16.00%,63.00%,23.00%,9.00%,均明显高于对照组,2组比较差异有显著性(P<0.05);观察组总胆汁酸(TBA)、总胆红素(TBiL)、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、碱性磷酸酶(ALP)值分别为(45.45±6.53)μmol/L、(40.31±7.34)μmol/L、(200.5±31.4)U/L,(190.5±29.6)U/L、(302.4±41.5)U/L,均明显高于对照组,2组比较差异有显著性(P<0.01)。结论妊娠期肝内胆汁淤积症容易引发胎儿呼吸窘迫,影响母婴健康,故加强监护、及时治疗、适时终止妊娠意义重大。

Objective The clinical data of patients with intrahepatic cholestasis of pregnancy women were analyzed,on the harm of the disease on pregnant women and fetus,and provide the basis for clinical therapy. Methods Bile of 100 cases of intrahepatic cholestasis of pregnancy women were analyzed,as the observation group, and compared with 100 cases of healthy pregnant women as control group,the pregnancy outcome were compared between the two groups,perinatal prognosis and the corresponding biochemical level. Results In the observation group,amniotic fluid contamination,fetal distress,cesarean section,premature delivery,postpartum hemorrhage rate were 18%,16%,63%, 23%,9%,were significantly higher than those in control group,the difference between the two groups was significant （P＆lt;0.05）;group TBA,TBIL,ALT,AST,ALP respectively （45.45 ＆#177;6.53）,（40.31 ＆#177;7.34μmol/L）μmol/L,（200.5 ＆#177; 31.4）U/L,（190.5 ＆#177;29.6）U/L,（302.4 ＆#177;41.5）U/L,were significantly higher than those in control group,the difference between the two groups was significant （P＆lt;0.05）.Conclusion Intrahepatic cholestasis of pregnancy can lead to fetal distress, effects of maternal and child health,so we need to strengthen the monitoring,the timely treatment,timely termination of pregnancy is important.