3Ilium L. Nasal drug delivery—possibilities, problems andsolutions. J Control Release, 2003 , 87(1 -3) : 187-198.
4Ilium L. Nasal drug delivery: new developments and strategies.Drug Discov Today, 2002,7(23) : 1184-1189.
5Merkus P, Romeijn SG, Verhoef JC, et al. Classification of cilio-inhibiting effects of nasal drugs. Laryngoscope, 2001,111(4 Pt1) : 595-602.
6Hofmann T,Gugatschga M,Koidl B, et al. Influence ofpreservatives and topical steroids on ciliary beat frequency in vitro.Arch Otolaryngol Head Neck Surg, 2004, 130(4) : 440-445.
7Cho JH, Kwun YS, Jang HS, et ai. Long-term use ofpreservatives on rat nasal respiratory mucosa : effects ofbenzalkonium chloride and potassium sorbate. Laryngoscope,2000, 110(2 Pt 1) : 312-317.
8Wang C, Deng Q, Han D, et al. Effects of benzalkonium chlorideand potassium sorbate on airway ciliary activity. ORL JOtorhinolaryngol Relat Spec, 2012, 74(3) : 149-153.
9Maliants R,Jorissen M,Augustijns P. Effect of preservatives onciliary beat frequency in human nasal epithelial cell culture : singleversus multiple exposure. Int J Pharm, 2007,338( 1-2) : 64-69.
10Lebe E, Baka M, Yava§oglu A, et al. Effects of preservatives innasal formulations on the mucosal integrity : an electronmicroscopic study. Pharmacology, 2004 , 72(2) : 113-120.