精液处理前后精液参数对夫精人工授精妊娠结局的影响

The influence of non-processed semen parameters and processed semen parameters on pregnancy outcome of husband sperm intrauterine insemination

目的：探讨精液处理前、后精液参数对以男性因素为主的宫腔内人工授精（ IUI）妊娠结局的影响。方法回顾性分析530个以男性因素为适应证在我中心接受IUI治疗的临床资料，按处理前、后的精子前向运动数和精子回收率进行分组，比较各组临床妊娠率。结果（1）根据处理前前向运动数分成三组：＜20×106/ml组、＞20～＜100×106/ml组和≥100×106/ml组，各组周期临床妊娠率分别为10.08％、12.79％和12.50％，各组妊娠率比较差异无统计学意义（P＞0.05）；（2）根据处理后前向运动数分成三组：＜10×106/ml组、＞10～＜20×106/ml组和≥20×106/ml组，各组周期临床妊娠率分别为8.42％、10.59％和12.57％，各组妊娠率比较差异无统计学意义（P＞0.05）；（3）根据处理后精子回收率分成两组：＜25％组和≥25％组，两组周期临床妊娠率分别为10.45％和12.76％，两组妊娠率比较差异无统计学意义（ P＞0.05）。结论 IUI的妊娠率随着精液处理前、后前向运动精子数和精子回收率的升高逐渐提高，但差异无统计学意义。

Objective To assess the effect of non-processed sperm parameters and processed sperm parame-ters on pregnancy outcome of husband sperm of intrauterine insemination （ IUI） .Methods A retrospective study was performed on 530 IUI cycles in our center .The cycles were divided in to 3 groups according to the processed （ or non-processed） progressive motile sperm count or sperm recovery rate .The clinical pregnancy rates among different groups were compared.Results （1）According to the non-processed progressive motile sperm count , the cycles were divided into 3 groups：〈20 ×106/ml, 〉20~〈100 ×106/ml and≥100 ×106/ml, the clinical pregnancy rates were 10.08%, 12.79%and 12.50%respectively, there were no significant differences among 3 groups（P〉0.05）;（2） According to the processed progressive motile sperm count the cycles were divided into 3 groups：〈10 ×106/ml, 〉10~〈20 ×106/ml and ≥20 ×106/ml, the clinical pregnancy rates were 8.42%, 10.59% and 12.57% respec-tively, there were no significant differences among 3 groups（P〉0.05）; （3）According to sperm recovery rate, the cycles were divided into 2 groups： 〈25%and≥25%, the clinical pregnancy rates were 10.45%and 12.57%re-spectively , there were no significant differences between two groups （ P〉0.05 ） .Conclusion With the increase of non-processed or processed progressive motile sperm count and sperm recovery rates , the IUI pregnancy rates gradual-ly increase , but there were no statistically difference .