Rho家族蛋白在胰腺癌组织中的表达及临床意义

Expression and clinical significance of Rho family proteins in pancreatic cancer

目的研究Rho家族中3个重要成员RhoA、RhoB、RhoC在胰腺癌组织中的表达及其临床意义。方法运用免疫组织化学SP法检测43例胰腺癌组织及25例正常胰腺组织中RhoA、RhoB、RhoC蛋白的表达情况,并分析它们的表达与胰腺癌临床病理特征之间的关系。结果 RhoA、RhoC蛋白在胰腺癌组织中的阳性表达率分别为76.7%和72.1%,在正常胰腺组织中的阳性表达率分别为28.0%和20.0%,两者比较差异均有统计学意义(P<0.05);RhoB蛋白在胰腺癌组织中的阳性表达率为4.7%,在正常胰腺组织中的阳性表达率为32.0%,两者比较差异有统计学意义(P<0.05);RhoA、RhoC蛋白表达均与胰腺癌的分化程度、肿瘤分期、有无淋巴结转移密切相关(P<0.05)。结论 RhoA、RhoC蛋白的表达与胰腺癌的发生发展、浸润转移密切相关。

[Objective] To investigate the expression of three important members of Rho family in pan- creatic cancer and their clinical significance. [Methods] The expression of RhoA, RhoB and RhoC was de- tected by immunohistochemistry （SP） method in 43 cases of pancreatic cancer, 25 cases of normal tissues, the relationship between expressions of RhoA and RhoC and clinicopathologieal features were analyzed. [Results] The positive rates of RhoA and RhoC are 76.7%, 72.1% in pancreatic carcinoma, which was significantly higher than those in normal pancreatic tissues （28.0% and 20.0%, respectively） （P〈0.05）; The positive rate of RhoB are 4.7% in pancreatic carcinoma, 32.0% in normal pancreatic tissues, There was significant difference （P〈0.05）; RhoA and RhoC expression were closely related with pancreatic cancer differentiation degree, TNM staging, lymph node metastasis （P 〈0.05）. [ Conclusion] The expression of RhoA and RhoC are closely related to the carcinogenesis, progress, invasion and metastasis of pancreatic carcinoma.