光学分子影像技术在疾病诊疗和药物研究中的应用

Application of optical molecular imaging technology in the diagnosis and treatment of diseases

光学分子影像学技术是发展迅速的生物医学影像技术之一,利用各种光学分子探针及成像技术、纳米技术等,对体内外细胞、组织、生物体等进行无创、实时、定位监测分子过程,以实现定性或定量动态研究。该技术灵敏度高、特异性强,尤其适用于小动物活体检测,为疾病诊断、新药临床前研究和新药开发提供有力的体内实时监测技术。本文综述了光学分子影像学的发展现状及荧光探针和纳米材料等在疾病诊断治疗、药物作用机制、肿瘤生物学等研究中的应用。

Optical molecular imaging （OMI） is one of the rapidly developing biomedical imaging technique employing different technologies, such as optical molecular probing, imaging and nanotechnology to monitor a local real-time non-invasive qualitative or quantitative dynamic studies both in vivo and in vitro. OMT＇s advantages, i. e. high sensitivity and specificity, especially in vivo studies, make it suitable for diagnosis, drug tracking in pre- clinical research and development of new drugs. Thus, it is regarded as a powerful real-time in vivo monitor. This paper discusses the latest advances in the use of fluorescent probes and nanomaterials in optical molecular imaging and its application in the diagnosis and treatment of diseases and in the studies of pharmacology and tumor biology.