栀子及其活性成分栀子苷防治糖尿病作用机制研究进展

Advance in studies on anti-diabetic mechanism of Gardeniae Fructus and its active ingredient geniposide

目前糖尿病的治疗以口服西药为主,疗效迅速,但临床中多有不良反应以及未能有效的防治并发症的报道,不适于长期使用,易产生耐药性。中医药治疗糖尿病,即中医理论所述的消渴症,历史悠久。近年来,不少学者以中药提取物或分离的活性成分为研究对象,以期开发出治疗、预防糖尿病的新型药物。因此,在这一领域出现了大量的研究报道。中药栀子及其环烯醚萜类活性成分栀子苷有着显著的降糖效果,并对糖尿病并发症有一定的治疗作用,应给予足够的重视。该文就栀子及栀子苷防治糖尿病的疗效及作用机制的研究进展进行了综述。

The diabetes is mainly treated by the oral administration of western medicines at present. Despite their rapid cura- tive effect, there have been still many reports for the western medicines about their clinical adverse reactions, failure of effective pre- vention and treatment of complications and drug resistance. Hence, they are not suitable for long-term administration. Traditional Chi- nese medicines have a long history in treating diabetes mellitus （ DM ）, which is commonly known as Xiaokezheng in the theory of tradi- tional Chinese medicines. In recent years, many scholars have taken extracts from traditional Chinese medicines or separated active con- stituents as the study objects in the expectation of developing new-type drugs for treating and preventing diabetes. Therefore, a large number of study reports have been emerged in this field. Due to their significant glucose-reducing effect and specific effect in treating complications of diabetes, traditional Chinese medicine Gardeniae Fruetus and its iridoid component geniposide shall he given full at- tention, This paper summarized the advance in studies on the curative effect and action mechanism of Gardeniae Fructus and geniposide in preventing and treating diabetes.