影响新生儿缺氧缺血性脑病发病的相关危险因素调查

Investigation on the related risk factors of neonatal hypoxic ischemic encephalopathy

目的:探讨新生儿缺氧缺血性脑病(HIE)发病的相关危险因素,为早期防治HIE提供依据。方法:采用病例对照研究法,将确诊的130例HIE患儿作为病例组,随机抽取同期住院的130例非HIE新生儿作为对照组,对所有研究对象进行临床流行病学调查,采用单因素非条件Logistic回归分析和多因素非条件Logistic回归分析法分析HIE发病的危险因素。结果:多因素Logistic回归分析结果显示妊娠期高血压疾病(HDCP)(OR=5.613)、妊娠期糖尿病(GDM)(OR=3.511)、不规范产前检查(OR=3.647)、产程异常(OR=3.819)、胎盘异常(OR=5.109)、胎儿窘迫(OR=3.347)、羊水污染(OR=2.892)、新生儿窒息(OR=2.532)、Apgar评分(OR=0.643)为HIE发病的相关危险因素。结论:应针对HIE发病的相关危险因素制定相应的预防措施。

Objective： To explore the related risk factors of neonatal hypoxic ischemic encephalopathy （HIE）, provide a basis for early prevention and treatment of HIE. Methods： A case - control study was conducted, 130 neonates with HIE were selected as case group, and 130 neonates without HIE during the same period were randomly selected as control group. A clinical epidemiological survey was performed in the two groups; univariate unconditional logistic regression analysis and multivariate unconditional logistic regression analysis were used to analyze the risk factors of HIE. Results： Multivariate unconditional logistic regression analysis showed that hypertensive disor- der complicating pregnancy （HDCP） （ OR = 5.613 ）, gestational diabetes mellitus （GDM） （ OR = 3.511 ）, non - standard prenatal exami- nation （ OR = 3. 647 ） , abnormality of labor （ OR = 3.819 ） , anomaly of placenta （ OR = 5.109 ） , fetal distress （ OR = 3. 347 ）, amniotic flu- id pollution （ OR = 2. 892 ） , neonatal asphyxia （ OR = 2. 532 ） and Apgar score （ OR = O. 643 ） . Conclusion ： Corresponding preventive measures should be designed targeting to the related risk factors of HIE.