强化他汀治疗在急性冠脉综合征患者PCI术后中的应用效果观察

Application efficacy observation of statin intensive treatment in acute coronary syndrome patients after PCI surgery

目的探讨急性冠脉综合征患者PCI术后应用强化他汀治疗的临床效果.方法选取本院2012年11月～2013年11月收治的88例急性冠脉综合征PCI术治疗的患者为研究对象,将其随机分成A组与B组,A组40例患者给予常规治疗,B组48例患者给予强化他汀治疗,观察两组患者的治疗效果.结果两组患者治疗后的胆固醇（TC）、低密度脂蛋白（LDL-C）、超敏C反应蛋白（hs-CRP）均较治疗前有所下降,B组下降更为明显,差异有统计学意义（P＜0.05）;治疗后两组患者的血浆丙氨酸氨基转移酶（ALT）、肌酐（Cr）均有所升高,但两组比较差异无统计学意义;A组患者心绞痛复发率为27.1％,心力衰竭发生率为18.7％,B组患者心绞痛复发率为15.0％,心力衰竭发生率为10.0％,B组患者的复发率及心力衰竭发生率明显低于A组,差异有统计学意义（P＜0.05）.结论急性冠脉综合征患者PCI术后应用大量他汀类药物进行强化治疗的临床效果较为显著,能显著改善患者的预后,值得在临床推广应用.

Objective To explore the clinical efficacy of applying statin intensive treatment to acute coronary syndrome （ACS） patients after PCI surgery. Methods Eighty-eight ACS patients who underwent PCI surgery admitted into our hospital from November 2012 to November 2013 were selected as research objects and randomly divided into group A and group B.In the group A （n=40）,patients were treated by regular therapy,while in the group B （n=48）,statin intensive treatment was provided.The efficacy in both groups were observed. Results After treatment,the total cholesterol （TC）,low density lipoprotein cholesterol （LDL-C）,and hypersensitive C reactive protein （hs-CRP） to some extent decreased in comparison with those before treatment in both groups.The decrease in the group B was more obvious with statistical differences （P〈0.05）.The alanine transaminase （ALT） and creatinine （Cr） after treatment both increased,but didn＇t dis- play a significant difference between the two groups.The recurrent rate of angina pectoris and incidence of cardiac fail- ure in the group A were 27.1% and 18.7%,while in the group B,they were 15.0% and 10.0% in turn,which were much lower than those in the group A and displayed statistical differences （P〈0.05）. Conclusion Application of substantial amount of statins for intensive treatment in ACS patients after PCI surgery can obtain remarkable clinical effect and improve patient＇s prognosis,which is worthy of expansion in clinic.