代谢综合征患者血浆醛固酮水平变化及其与代谢综合征组分相关性研究

The change in the level of aldosterone in patients with metabolic syndrome(MS) and its correlation with separate components of MS

目的探讨MS患者中血浆醛固酮(Ald)水平变化及其相关性。方法采用放射免疫分析法测定MS组(n=248)和NC组(n=240)血浆肾素及Ald水平,对糖脂代谢相关指标进行组间比较,并对MS患者血浆Ald水平与年龄、BP及糖脂代谢指标进行相关性分析。结果 MS组血浆Ald水平、BMI、BP、FPG、FIns、HOMA-IR、TG及LDL-C水平均高于NC组(P均<0.05),两组肾素活性比较,差异无统计学意义。多元逐步回归分析及相关分析显示,血浆Ald水平与FPG、HOMA-IR、SBP、BMI呈正相关(r=0.204、0.335、0.216、0.341,P均<0.05)。结论 Ald独立作用于MS及其各组分的发生、发展。

Objective To observe the changes of aldosterone level in patients with metabolic syndrome and to explore the relation between aldosterone and metabolic syndrome.Methods Serum renin and aldosterone levels of 248 patients with metabolic syndrome and 240 participants in control group were assayed by RIA.The parameters related to glucolipid metabolism were compared among two groups.Meanwhile correlation analysis was conducted between levels of serum aldosterone and parameters of age,blood pressure,glucolipid metabolic indexes in patients with MS.Results The levels of serum aldosterone,body mass index,blood pressure,blood glucose,serum insulin,HOMA-insulin resistance index,serum triglycerides and low density lipoprotein were significantly higher in MS group than in control group （P〈0.05）.There was no significantly difference in plasma renin activity between two groups.In multivariable models,plasma aldosterone was positively associated with blood glucose,HOMA-IR,systolic pressure and body mass index （r =0.204,0.335,0.216,0.341,all P 〈 0.05）.Conclusion Plasma aldosterone is independently associated with the metabolic syndrome and its separate components.