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C2CD4A/C2CD4B基因多态性与2型糖尿病相关性的研究 被引量：1

Correlation research of C2CD4A/C2CD4B gene polymorphism with type 2 diabetes
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摘要 T2DM是以IR和糖脂代谢异常为特征的一种内分泌及代谢疾病。C2CD4A/C2CD4B主要存在于内皮细胞。C2CD4A/C2CD4B属于同一个基因家族,可编码核因子、调节可控制细胞结构基因的功能。多项研究提示,C2CD4A和C2CD4B基因多态性与T2DM发生、发展有关,但其影响血糖稳态的分子生物学机制尚不明确。 T2DM is a kind of endocrine and metabolic disease characterized by insulin resistance and glucolipid metabolism disorder. C2CIMA and C2CD4B gene were found predominantly in endothelial cells. C2CD4A and C2CIMB belong to a gene family encoding nuclear factors with a role in regulating genes which control cellular architecture. Several studies suggest that C2CIMA and C2CD4B gene polymorphism are associated with T2DM genesis and development. However, molecular mechanism of C2CINA and C2CIMB gene influencing on glucose homeostasis remains unclear.
作者 孙璐璐 乔虹
机构地区 哈尔滨医科大学附属第二医院综合内科
出处 《中国糖尿病杂志》 CAS CSCD 北大核心 2014年第4期379-381,共3页 Chinese Journal of Diabetes
基金 国家自然科学基金(81172742)
关键词 C2CD4A C2CD4B 基因多态性 糖尿病 2型 C2CD4A/C2CD4B Gene polymorphism Diabetes mellitus, type 2
分类号 R587.1 [医药卫生—内分泌]
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参考文献12

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中国糖尿病杂志
2014年 第4期

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