摘要
目的獉獉:探究M1受体的阻断剂及M4受体的激动剂对吗啡诱导的条件性位置偏爱表达的影响。方法獉獉:采用大鼠吗啡条件性位置偏爱(CPP)模型及脑部核团微注射的方法。结果獉獉:与生理盐水对照组相比,M1受体拮抗剂Pirenzepine可以增强吗啡CPP的表达,M4受体激动剂LY2033298也可以增强吗啡CPP的表达。结论獉獉:伏隔核的M1和M4型受体参与吗啡奖赏记忆的表达。
Objective：To explore the roles of M1 and M4 muscarinic acetylcholinergic receptors in the expression of morphine - induced conditioned place preference （CPP）, Methods： The model of morphine -induced CPP in rat and the microinjections into nucleus aecurnbens were adopted. Results：It was found that the antagonist of M1 receptor （ Pirenzepine ） enhanced the expression of morphine - induced CPP, and that the agonist of M4 receptor （LY2033298） also amplified the expression of morphine - induced CPP. Conclusion： The M1 and M4 receptors in nucleus accumbens play roles in the modulation of morphine reward memory.
出处
《中国药物依赖性杂志》
CAS
CSCD
2014年第2期93-98,共6页
Chinese Journal of Drug Dependence
基金
国家自然科学基金(30873051
81271473)
北京市自然科学基金(7112087)
关键词
毒蕈碱乙酰胆碱受体
吗啡
条件性位置偏爱
muscarinic acetylcholonergic receptor
morphine
conditioned place preference （CPP）
