人食管鳞癌组织中DDR1表达及预后意义

Expressions of DDR1 and its significance in the prognosis of esophageal squamous cell carcinoma

目的研究DDR1在人食管鳞癌中的表达,探讨DDR1的表达与人食管鳞癌临床病理特征以及预后关系。方法运用免疫组织化学方法检测人食管鳞癌组织中的DDR1的表达,并结合患者的临床病理特征和生存情况进行分析。结果食管鳞癌组织DDR1阳性表达为63.3%(38/60例),显著高于癌旁组织(P=0.002),DDR1在食管鳞癌组织中的阳性表达率与分化程度和淋巴结转移、浸润深度、TNM分期密切相关(P<0.05)。多因素分析提示DDR1阳性、TNM分期是食管鳞癌预后的独立危险因素(P<0.05)。结论 DDR1阳性表达与肿瘤的复发、转移密切相关,可作为评估食管鳞癌患者的不良预后指标。

【Objective】This study aimed to examine expression of Discoidin Domain Receptor-1（DDR1） in esophageal squamous cell carcinoma（ESCC） tissues, to investigate the relationship of DDR1 with clinicopathological features, and to estimate the prognostic value of DDR1. 【Methods】The expression of DDR1 protein was detected by immunohistochemistry in ESCC, the correlation among DDR1 expression, pathological features, and clinical outcomes were investigated.【Results】We found DDR1 expression was positive 38（40%） of 60 cases, DDR1 expression was higher in the esophageal tumor tissues than in the paracancer tissues（P =0.002）. and the positive expression rate of DDR1 in ESCC were correlated with degrees of differentiation、lymphnode metastasis,invasion depth of carcinoma and TNM stage（P 0.05）. Multivariate analysis showed that DDR1,TNM-stage was an independent prognostic marker for ESCC recurrence. 【Conclusions】DDR1 is associated with outcome of ESCC, which may be used as a poor prognosis marker of ESCC.