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拉米呋定合成研究进展 被引量:2

Progress on Total Synthesis of Lamivudine
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摘要 综述了拉米呋定 ( Lamivudine)全合成研究进展。参考文献 1 6篇。 The progress on the total synthesis of the Lamivudine was reviewed with 16 references.
出处 《合成化学》 CAS CSCD 2001年第1期21-26,共6页 Chinese Journal of Synthetic Chemistry
关键词 拉米呋定 BCH-189 抗艾滋病药物 全合成 lamivudine BCH-189 HIV review
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参考文献4

  • 1Jin Haolun,J Org Chem,1995年,60卷,2621页
  • 2Chang C N,J Biol Chem,1992年,33卷,6899页
  • 3Chung K,Schinazi J Org Chem,1991年,56卷,6503页
  • 4Lin T S,Biochem Pharmacol,1987年,36卷,311页

同被引文献23

  • 1蓝晓红,王莉,李艳丽.近年来贺普丁应用的评述与研究[J].中国新医药,2003,2(6):48-50. 被引量:3
  • 2张兆颖.拉米夫定临床研究进展[J].抗感染药学,2005,2(1):4-6. 被引量:13
  • 3谌宁生.中药联合拉米夫定治疗慢性乙型肝炎的临床研究进展[J].中西医结合肝病杂志,2006,16(6):379-381. 被引量:6
  • 4JIN H, SIDDIQUI M A, EVANS C A, et al. Diastereoselective synthesis of the potent antiviral agent (-)- 2-deoxy-3'-thiacytidine and its enantiomer[J]. Journal of Organic Chemistry, 1995,60(8) : 2621-2623.
  • 5BELLEAU B, BELLEAU P, NGUYEN B N. Preparation of 2-( hydroxymethyl )-5-cytosinyl-1, 3-oxathiolanes and analogs as virueides[P]. US:5047407,1991- 09-10(CA 1991,114 : 43492).
  • 6WARREN B J, J EONG L S, ALVES A J, et al. Synthesis of enantiomerically pure (2'R,5'S)-(-)-1-[2-(hydroxy-methyDoxathiolan-5-yl]eytosine as a potent an- tiviral agent against hepatitis B virus (HBV) and human immunode ficiency virus (HIV) [J]. Journal of Organic Chemistry, 1992,57(8) : 2217-2219.
  • 7JEONG L S, SCHINAZI R F, BEACH J W, et al. Asymmetric synthesis and biological evaluation of β-L- (2R, 5 S)-and α-L- ( 2R, 5R)- 1,3-oxathiolane-pprimidine and-purine nucleosides as potential anti-HIV agents[J]. Journal of Medicinal Chemistry, 1993,36 (2) : 181-195.
  • 8TYRRELL D L J,MITCHELL M C,DEMON R A,et al. Phase Ⅱ trail of lamivudine for chronic hepatitis B [J].Hepatology, 1993,18 (4) : 112A.
  • 9CHOI W B, WILSON L J, YEOLA S, et al. In situ complexa-tion directs the stereochemistry of N-glycosylation in the synthesis of thialanyl and dioxolanyl nucleosides analogues[J]. Journal of the American Chemical Society, 1991,113(24) : 9377-9379.
  • 10HUMBER D C,JONES M F,PAYNE J J,et al. Expeditious preparation of (-)-2'-deoxy-31-thiacyti-dine (3TC) [J].Tetrahedron Letters, 1992,33 (32):4625-4648.

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