发散法合成树枝状高分子聚酰胺-胺

Synthesis of Starburst Dendrimers Polyamidoamine by Divergent Synthesis

采用发散法 ,以乙二胺为原料 ,通过与丙烯酸甲酯和乙二胺进行 Mickeal加成和酰胺化缩合反应 ,合成了以乙二胺为核、支化代为 1 .0的树枝状高分子聚酰胺 -胺 ,讨论了反应温度、反应时间和投料摩尔比等因素对反应的影响 ,同时讨论了该反应的特点。结果表明 :适宜的反应温度为 2 5℃ ,反应时间为 2 4 h,投料比为 mol0 .5代 PAMAM∶ mol乙二胺 =1∶ 2 4 ,在此条件下 ,产品的产率为 99.9% ,纯度在 99%以上。

The 1.0G polyamidoamine(PAMAM) has been synthesized by divergent synthesis using ethylenediamine as a raw material by means of Mickeal addition reaction and amidation reaction with methyl acrylate and ethylenediamine. The effects of reaction temperature, reaction time, the ratio of feed on the reaction were examined and the reaction characteristic was discussed. According to the experimental result, when the temperature was 25℃, the time was 24h and the ratio of feed was 1∶24, the yield of the products was 99.9% with purity over 99%.