急性白血病患者血清及头发中8种微量元素的研究

A STUDY ON THE LEVELS OF TRACE ELEMENTS(Se Zn Ge Cu Co V Sr Ti) IN THE SERUM AND HAIR OF ACUTE LEUKEMIA

用原子吸收光谱技术测定30例急性白血病及配对30例健康人血清及头发中的Se、Z n、Ge、Cu、Co、V、Sr、Ti等8种微量元素.结果:急性白血病患者血清及头发中的Se、Zn、Ge、Co、V等的含量均明显低于对照组(P<0.01),而Cu、Sr则高于对照组,除头发Cu外,两组也有显著性差异(P<0.01).血清及头发Ti略高于对照组,但无统计学意义(P>0.05).急性白血病患者入院后死亡组与完全缓解(CR)组血清及头发中8种微量元素含量,除死亡组头发Cu高于CR组有显著意义(P<0.05)外,其余元素两组间均无差异,提示急性白血病患者体内微量元素改变对预后似无意义.

Eight trace elements (Se Zn Ge Cu Co V Sr Ti) in the serum and hair of 30 acute leukemic patients and 30 healthy controls were determined by atomic absorption spectrometry.The results were as follows: (1) The levels of Se Zn Ge Co V in the serum and hair of the leukemic patients were significantly lower than those of the controls (P<0.01); But, with the exception of Cu in the hair, Cu Sr of the leukemic patients were significantly higher than the controls (P<0.01).There were no differences in the levels of Cu Ti in the hair and Ti in the serum between the leukemic patients and the controls (P>0.05).(2) When the levels of the eight trace elements in the serum and hair of the leukemic patients who had died in the hospital were compared with of the leukemic patients who had complete remission, there were no differences between these two groups (P>0.05),except Cu in the hair.The level of Cu in the hair of the patients who had died was higher than those patients who had complete remission (P<0.05).Thus, the changes of the levels of the eight trace elements in the leukemic patients seemed to be of not much value in comprehending the prognosis of the patients.