2,5-联苯二甲酸的新合成方法

A new method for Synthesis of 2,5-Biphenylodicarboxlic acid

铁粉催化下 ,对二甲苯于室温与溴反应 ,得到 2 -溴对二甲苯 ,将其制备成相应的格氏试剂 ,在 Ni Cl2 ( PPh3) 2 催化下与溴苯进行交叉偶联 ,得到 2 ,5-二甲基联苯 ,再用高锰酸钾水溶液氧化 ,合成标题化合物。产物的结构由 IR确认。

The p xylene reacts with Br 2 in the presence of Fe filing at room temperature to give 2\|bromo\|p\|xylene.The 2\|bromo\|p\|xyiene is converted to grignard reagent,which reacts with bromobenzene in the presence of NiCl 2 (PPh 3) 2,a selective cross\|coupling catalyst, 2,2 dimethylbiphenyl is synthesized,the 2,5\|dimethylbiphenyl is oxidated with KMnO 4 to give the title compound.The structure of product is identified by IR.