利普刀治疗宫颈上皮内瘤变的临床疗效观察及安全性分析

Analysis of clinical effects and safety of loop electrosurgical excision procedure in the treatment of cervicaI intraepithelial neoplasma

目的比较利普刀锥切术与冷刀锥切术治疗宫颈上皮内瘤变(CIN)的疗效。方法 100例CIN的患者,随机分为A组和B组各50例,其中A组采用普刀锥切术,B组采用冷刀锥切术,观察两组临床疗效及不良反应。结果 A组治愈率明显高于B组,差异有明显的统计学意义(P<0.05),A组患者手术时间、术中出血量、住院时间及治疗费用均明显低于B组患者,差异有明显的统计学意义(P<0.05),两组患者不良反应发生率无明显的统计学差异(P>0.05)。结论利普刀治疗宫颈上皮内瘤变患者具有治愈率高、手术时间短、术中出血量少、愈合时间快、住院天数少和治疗费用低的优点,值得临床推广应用。

Objective To compare the effectiveness of loop electrosurgical excision procedure （LEEP） and cold knife conization in the treatment of cervical intraepithelial neoplasma （CIN）. Methods One hundred cases of CIN were randomly divided into group A and group B, each had 50 cases. Group A was treated by LEEP, Group B was treated by cold knife eonization. The clinical efficacy and side - effect were ob- served and compared between two groups. Results Cure rate in group A was significantly higher than that in group B, the difference was statisti- cally significant （ P 〈 0.05 ）. The operative time, blood loss, hospital stay and treatment costs in group A were significantly lower than group B （ all P 〈 0.05 ）. There was no significant statistical difference in the incidence of adverse reactions between two groups. （ P 〉 0.05 ）. Conclusion LEEP has the advantages in operation time, amount of blood loss, healing time, hospitalization time and treatment expenses, it is worth to be recommended.