2型糖尿病患者发生糖尿病肾病的相关因素分析

Study on related factors for occurrence of diabetic nephropathy in patients with type 2 diabetes

目的探讨2型糖尿病患者糖尿病肾病发生的相关因素。方法采取回顾性分析方法选取2008年1月1日至2012年12月31日间门诊的868例2型糖尿病患者,按尿微量白蛋白(MAU)水平分成两组:无糖尿病肾病组和糖尿病肾病组,对两组患者的临床数据进行比较。结果①868例2型糖尿病患者中糖尿病肾病250例,占28.8%。②两组间年龄、病程、体重指数(BMI)、收缩压、舒张压、空腹血糖、餐后2小时血糖、糖化血红蛋白(HbA1c)、空腹胰岛素、胰岛素抵抗指数,胆固醇(TC)、甘油三酯(TG)、尿酸(UA)差异具有统计学意义。③Logistic回归分析结果提示:糖尿病肾病与BMI、收缩压、空腹血糖、HbA1c、TG、UA相关。结论 2型糖尿病患者应综合控制体重、血压、血糖、血脂、UA,改善代谢紊乱情况,利于糖尿病肾病的防治。

Objective To explore the risk factors responsible for occurrence of diabetic nephropathy in patients with type 2 diabetes melli- tus. Methods A total of 868 outpatients with type 2 diabetes mellitus during January 1,2008 to December 31,2012 were divided into two groups according to level of microalbumiuria （MAU） ： diabetic nephropathy group and non - diabetic nephropathy group. The clinical data of patients in these 2 groups were compared in order to find out the risk factors responsible for diabetic nephropathy. Results （1）Among 868 patients, 250 of them had diabetic nephropathy, accounted for 28.8%. （2）The diference in age, course of disease, body mass index （BMI）, systolic blood pres- sure, diastolic blood pressure, fasting blood - glucose, 2 - hour postprandial blood - glucose, glycosylated hemoglobin （ HbA1 c）, fasting insulin, insulin resistance index, total cholesterol （TC）, triglyceride （TG） and uric acid （UA） between two groups were statistically significant. （3）The result of Logistic regression analysis showed that BMI, systolic blood pressure, fasting blood - glucose, HbA1c, TG and UA were all relevant to the occurrence of diabetic nephropathy. Conclusion Patients with type 2 diabetes mellitus should control their body weight, blood pressure, blood levels of glucose and lipid in order to prevent the occurrence of diabetic nephropathy.