丹参多酚酸盐治疗非ST段抬高型心肌梗死临床研究

Clinical Observation of Salvianolate in Treating Great Aged Patients with Non-ST-elevated Myocardial Infarction

目的探讨丹参多酚酸盐治疗老年高龄非ST段抬高型心肌梗死的临床疗效。方法 72例非ST段抬高型心肌梗死患者随机分成2组,丹参多酚酸盐组37例,常规治疗组35例,2组给予相同的常规基础治疗,治疗组加用丹参多酚酸盐200 mg静滴,1次/d,持续10 d;监测2组治疗前后cTnI、CRP、BNP水平变化,血液流变学指数变化,左室舒张功能变化及用药期间的不良反应。结果 2组用药后cTnI、CRP、BNP水平变化,血液流变学指数变化,左室舒张功能变化均有明显改善(P<0.05),治疗组与对照组治疗后组间比较差异有统计学意义(P<0.05),未出现不良反应事件。结论在常规基础上联合丹参多酚酸盐治疗老年高龄非ST段抬高型心肌梗死的效果显著,能有效缓解患者的症状,提高疗效,改善预后。

Objective To observe the effects of salvianolate in treating great aged patient with non-ST-elevated myocardial infarction. Methods A total of 72 subjects were randomized into two groups（ 37 in trial group ;35 in control group） and treated by routine treatment; trial group was additionally given salvianolate （ 200 mg, once a day, 10 days）. The levels of serum cardiac troponin I （ cTnI）, C-reaction protein （CRP） and brain natriuretic peptide （ BNP ）, hemorheology, and left ventricular diastolic function before and after treatment were detected in both groups, and adverse effects were also moni- tored during treatment. Results The levels of cTnI, CRP and BNP, hemorheology and left ventricular diastolic function were all improved significantly in each group after treatment （ P 〈 0.05 ） , and there were also differences in trial group compared to control group after treatment（ P 〈 0.05 ）. No adverse effect was detected in this study. Conclusion Salvi- anolate combined with conventional treatment was good for great aged patient with non-ST-elevated myocardial infarction, and was responsible for improving clinical symptom, curative effect and prognosis.