4-(4,6-二吗啉-1,3,5-三嗪-2-基)苯胺的合成

Synthesis of 4-( 4,6- dimorpholino- 1,3,5- triazin- 2- yl) aniline

目的合成4-(4,6-二吗啉-1,3,5-三嗪-2-基)苯胺。方法三氯聚氰与吗啉在冰浴条件下经取代反应制得4,4’-(6-氯-1,3,5-三嗪-2,4-二基)二吗啉,再与苯胺-4-硼酸频那醇酯经Suzuki反应制得4-(4,6-二吗啉-1,3,5-三嗪-2-基)苯胺。结果与结论结构经核磁及质谱确证,总收率约61.7%。

Objective To synthesize 4 - （4,6 - dimorpholino - 1,3,5 - triazin - 2 - yl ） aniline. Methods 4,4＇ - （ 6 - chloro - 1,3,5 - triazine - 2,4 - diyl ） dimorpholine was synthesized with 2,4,6 - trichloro - 1,3,5 - triazine anti mor- pholine by substitution reaction under ice bath,and then reacting with amino - phenyl -4 - boronic acid pinacol ester to ob- tain 4 - （ 4,6 - dimorpholino - 1,3,5 - triazin - 2 - yl ） aniline by Suzuki reaction. Results and Conclusion The structure was confirmed by I H -NMR and ESI -MS,the overall yield was 61.7%.