血清PABA的测定对胰腺外分泌功能试验的价值

THE ROLE NBT-PABA TEST IN EVALUATING PANCREATIC EXOCRINE FUNCTION

给58例受试者口服N—苯甲酰—L—酪氨酰—对氨基苯甲酸(NBT—PABA),测定血清及尿的PABA的含量。结果30例正常人服NBT—PABA后血清PABA的浓度3h达高峰,峰值为32.340±7.350μmol/L。21例非胰腺消化系疾病组峰值为30.940±8.160μmol/L。7例慢性胰腺炎3h峰值为20.965±10.304μmol/L。与对照组比较有显著性差异(P<0.002)。而且一直延迟到6h仍未明显下降。结果表明口服NBT—PABA 3h后血清PABA的浓度对胰腺外分泌功能的判断有一定的价值。

58 subjects were tested for pancreatic function using N-benzoy-L -tyrosyl--PABA (NBT--PABA) test, in which their serum and urine para-aminobenzoic acid (PABA)were determined simulta-neously. The mean serum PABA peak level at three hours in the 30 controls was 32. 340±7. 350 μmol/L,that of the 21 patients with non pancreatic digestive system disease was 30. 940±8. 160 μmol/L, and that of the 7 patients with chronic pancreatitis was 20. 965±10. 304 μmol/L. Such differences between the controls and the patients with chronic pancreatitis were very significant (P< 0. 002). Also the serum PABA concentration of the patients with chronic pan creatitis did ont reduce even after six hours.The results of our study show that determination of serum PABA concentration after three hours ingestion of NBT--PABA is a valuable index for evaluating pancreatic exocrine function.