喜炎平联合左氧氟沙星治疗慢性阻塞性肺疾病伴感染疗效观察

The Effect Observation of Xiyanping in Combination with Levofloxacin in the Treatment of Chronic Obstructive Pulmonary Disease with Infection

目的观察喜炎平注射液联合左氧氟沙星治疗慢性阻塞性肺疾病伴感染的临床疗效。方法将82例患者随机分为两组,均予控制性氧疗、抗生素、糖皮质激素、支气管扩张剂、祛痰剂等,同时纠正水电解质紊乱及酸碱平衡失调等。治疗组(喜炎平注射液联合左氧氟沙星治疗组)及对照组(左氧氟沙星组),各组均治疗10 d;比较各组临床疗效及细菌清除率。结果对照组:痊愈16例,显效6例,进步15例,无效3例,有效率55%;治疗组:痊愈20例,显效14例,进步3例,无效5例,有效率80.9%;治疗组与对照组有效率差异具有统计学意义(χ2=8.571,P=0.003)。82例患者培养出致病菌52例(每组各26例),经过治疗,两组肺炎克雷伯杆菌、流感嗜血杆菌、绿脓杆菌、金黄色葡萄球菌、大肠杆菌及肺炎链球菌清除率比较,差异有统计学意义(P<0.01),治疗组总清除率为69.2%,对照组为38.5%;表皮葡萄球菌、卡他球菌清除率差异均无统计学意义(P>0.05)。结论喜炎平联合左氧氟沙星治疗慢性阻塞性肺疾病伴感染疗效满意,无明显不良反应。

Object ive To observe the clinical effects of Xiyanping injection in combination with levofloxacin to cure chronic ob-structive pulmonary diseases with infection.Methods 82 patients were randomly divided into two groups.All patients were treated with controlled oxygen therapy, antibiotics, corticosteroids, bronchodilators, expectorants, while at same timecorrecting water electro-lyte imbalance and acid-base imbalance etc.The treatment group （ n=41 ） was cured with Xiyanping injection in combination with levofloxacin .The control group （ n=41 ） was cured with levofloxacin .The control group and treatment group were all treated for 10 days, and the clinical effect and bacterial clearance were compared.Results In the control group, 16 cases recovered, 6 cases were effective, 15 cases progressed, 3 cases were invalid, and the effective rate was 55.0%.In the treatment group, 20 cases recovered, 14 cases were effective, 3 cases progressed, 5 cases were invalid, and the effective rate is 80.9%, there was statistically significant difference in the effective rate （χ2=8.571, P=0.003） between the treatment group and the control group.Of 82 patients, cultured pathogens were cultured in 52 cases （26 cases in each group）.After treatment, there was between the two groups statistically signifi-cant difference （ P〈0.01 ） in the bacterial clearance of Klebsiella pneumoniae , haemophilus influenzae ,Pseudomonas aeruginosa , Staphylococcus aureus, escherichia coli and streptococcus pneumoniae .The total bacterial clearance of the treatment group was 69.2% and the total bacterial clearance of the control group was 38.5%.There was no statistical significance in the bacterial clearance of staphylococcus epidermidis and catarrhal coccus of the two groups （ P〉0.05 ） .Conclusion The effect of Xiyanping injection in combination with levofloxacin in the treatment of chronic obstructive pulmonary disease with infection was satisfactory , and there was no significant adverse reaction.