头孢呋辛钠、头孢呋辛赖氨酸与5种输液的配伍稳定性研究

The stability study of the compatibility of cefuroxime sodium,cefuroxime lysine with five infusion solutions

目的考察并比较注射用头孢呋辛钠、注射用头孢呋辛赖氨酸与5种输液在不同温度(4℃、25℃)、不同光照(光照强度2500 Lx、避光)下6h内的配伍稳定性。方法模拟临床用法,通过外观、不溶性微粒、pH检查和含量测定,考察6h内两种药物在5种输液中的稳定性。结果两种药物与5种输液配伍后溶液pH变化有差别。头孢呋辛钠与碳酸氢钠溶液配伍后产生白色浑浊;光照影响头孢呋辛钠与5%葡萄糖、果糖注射液的配伍稳定性。头孢呋辛赖氨酸与5种输液配伍6h内含量稳定(P>0.05),溶液外观、不溶性微粒及pH均无明显变化。结论头孢呋辛钠与注射用碳酸氢钠溶液存在配伍禁忌,与5%葡萄糖注射液、果糖注射液配伍时应避光使用。头孢呋辛赖氨酸与5种输液6h内配伍稳定性良好,弥补了头孢呋辛钠配伍使用的不足。

Objective To study and compare the compatibility of cefuroxime sodium and cefuroxime lysine with five infusion solutions at different temperature （4 ℃ and 25 ℃） and different illumination （2500 Lx and away from light） within six hours. Methods The appearance, insoluble particles, pH and content of the complexes of two drugs which were prepared based on the clinical medication were determined under different conditions in six hours. Results The pH value of complexes varied differently in compatible solutions of two drugs. White sediment appeared in the compatible solutions of cefuroxime sodium with sodium carbonate infusion solution. The light affected the stability of the mixtures of cefuroxime sodium with 5% glucose infusion solution or fructose infusion solution. The appearance, insoluble particles and content of cefuroxime lysine compatible solutions varied slightly in six hours （/〉〉0.05）. Conclusion Cefuroxime sodium and sodium carbonate infusion solution was incompatible. 5% glucose infusion solution or fructose infusion solution mixed with cefuroxime sodium should be protected from light. The five infusion solutions mixed with cefuroxime lysine were stable in six hours, which made up the defect of the compatible use of cefuroxime sodium in some extent.