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可用于制备非天然氨基酸的新型甘氨酸Ni(Ⅱ)螯合物的合成

Synthesis of novel Ni(Ⅱ)-complexes of glycine for preparation of unnatural amino acid
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摘要 目的为了研究非天然氨基酸的合成,推广其在现代制药工业中的应用,设计并合成了环苏氨酸(丝氨酸)洐生化的甘氨酸Ni(Ⅱ)螯合物。方法以苏氨酸(丝氨酸)为原料,通过与甲醛成环,(Boc)2O保护氨基,再与2-氨基-二苯甲酮成酰胺,脱Boc上的苄基后,最后与Gly和Ni(Ⅱ)在碱性环境下形成平面正方形螯合物。结果和结论目标化合物Ⅱa^d及Ⅲ经1HNMR、MS确证结构。 OBJECTIVE To design and synthesize a Thr （Ser） - derived Ni （Ⅱ） - complexes of glycine to study the synthesis of nonproteinogenic α - amino acids and extend them being used in the modern pharmaceutical industry. METHODS L - Thr （Ser） used as starting material was reacted with formaldehyde, protected by （Boc）20, amidated with 2 -aminobenzophenone, then Boe was removed and the product was N - alkylated with benzyl group, at last square - planar Ni （Ⅱ） - complexes of glycine was obtained. RESULTS and CONCLUSION The target compounds Ⅱ a - d and Ⅲ were confirmed by t HNMR, MS.
作者 陈正军 何谷 郭丽
机构地区 四川大学华西药学院 四川大学生物治疗国家重点实验室
出处 《华西药学杂志》 CAS CSCD 北大核心 2014年第2期109-112,共4页 West China Journal of Pharmaceutical Sciences
基金 国家自然科学基金资助项目(批准号:81001357)
关键词 苏氨酸 丝氨酸 非天然氨基酸 甘氨酸Ni(Ⅱ)螯合物 合成 Threonine Serine Nonproteinogenic amino acids Ni （Ⅱ ） - Complexes of Glycine Synthesis
分类号 R914 [医药卫生—药物化学]
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参考文献10

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