缺血性卒中后非流利型失语患者静息态功能磁共振比率低波振幅的研究

Resting-state fMRI fALFF analysis in patients with non-fluent aphasia after ischemic stroke

目的:对缺血性卒中后非流利型失语症患者的静息态功能磁共振原始数据进行比率低频振幅的处理分析,探讨其脑功能损伤及代偿的病理机制。方法:对17例失语患者(患者组)及19例年龄、性别、受教育程度均匹配的健康对照者(正常组)进行静息状态下的功能磁共振成像扫描,扫描序列为回波平面成像序列,应用DPARSF软件进行数据处理,并进行对比分析。结果:同正常组比较,患者组右侧颞上回、顶下小叶、中央后回及额叶皮层的fALFF值增高;右侧丘脑及双侧的小脑半球的fALFF值明显降低。结论:静息状态下,缺血性卒中后非流利型失语的患者在某些脑区存在异常激活,反映其脑功能失调的病理变化,为临床从大脑神经活动层面进一步了解失语症损伤及其代偿过程提供了客观依据。

Objective To understand the impairment and compensation mechanism of brain function in pa- tients with non-fluent aphasia after ischemic stroke. The fractional amplitude of low frequency fluctuation （fALFF） method was used to analyze the functional magnetic resonance imaging （fMRI） data in the resting state between the aphasia patients and the normal controls. Methods The scans of the resting state of fMRI were performed in 17 aphasia patients and 19 age-, education-, and sex-matched healthy control subjects. The scan sequence was single- shot echo planar image, DPARSF software was used to analyze fALFF data of the aphasia patients and the healthy controls. Results Compared to the control group, the value in right superior temporal gurus, inferior parietal lob- ule, frontal lobe cortex, and postcentral gurus were significantly increased in the aphasia group. The fALFF in bilat- eral cerebellum and right thalamus were also decreased in the aphasia group. Conclusions The fALFF values in some brain region in the aphasia group were abnormal in the resting state, indicating a few pathological change of brain function in patients with non-fluent aphasia after isehemic stroke.