摘要
药物代谢组学是通过用药前代谢产物的特点来预测对个人进行药物或外来物干预的结果,主要目标是寻找出与疾病相关的、具有个体差异、能代表个体代谢水平的生物标记物或生物标记组,对药物安全性评价及个体化治疗将起到重要作用。
Pharmaco-metabonomics can predict the outcome of a drug or xenobiotic intervention in an individual based on a mathematical model of pre-intervention metabolite signatures.Its main objective is to find disease-related biomarkers or biomarkers group with individual differ-ences and on behalf of individual metabolism.Pharmaco-metabonomics will play an important role in drug safety evaluation and individualized therapy.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2014年第4期374-376,共3页
The Chinese Journal of Clinical Pharmacology
基金
国家重大新药创制课题基金资助项目(2012ZX09303004-002)
关键词
药物代谢组学
个体化治疗
药物安全性评价
pharmaco -metabonomics
individualized therapy
drug safety evaluation
