摘要
目的探讨纳米羟基磷灰石人工骨(Nano-HA)修复骨缺损的临床效果。方法回顾性分析了2009年9月~2012年6月采用Nano-HA人工骨治疗的27例骨缺损患者,骨缺损范围为0.3cm×1.0cm^3.0cm×6.5cm,人工骨植入量为3~15 g。部位包括肱骨、桡骨、尺骨、股骨、胫骨、跟骨。骨缺损原因包括骨折22例,骨肿瘤5例。分别在术后1周、1个月和3个月进行临床和X线片检查,观察治疗效果。结果随访时间11个月~26个月,平均18.5个月,骨缺损区Nano-HA与宿主骨直接愈合,相容性好,与原骨界面间无间隙,术后观察未见不良反应。结论 Nano-HA人工骨具有良好的生物相容性,是一种理想的骨缺损修复材料。
Objective To study the clinical effect of nano-hydroxyapatite（Nano-HA） artificial bone on repairing bone defects. Methods From Sep. 2009 to Jun. 2012, 27 cases of bone defect were collected retrospectively. The bone defect ranged from 0.3crux 1.0cm to 3cm× 6.5cm, which including the bone defects of humerus, radius, ulna, femur, tibia, and calcaneus. Among them, 22 cases suffered from fractures and 5 cases tumors. All patients were treated with Nano-HA artificial bone. Observation was applied on healing of wounds and X-ray exams preoperatively and postoperatively. Results The patients were followed up from 11 month to 26 months （averagely 18.5 months）. X-ray photo showed an integrity interface between Nano- HA and bone. Primary healing was obtained in all cases without any complication： Conclusions The Nano- HA artificial bone has a good biocompatibility. It may be an ideal artificial material to reconstruct bone defect.
出处
《中国临床解剖学杂志》
CSCD
北大核心
2014年第2期206-209,共4页
Chinese Journal of Clinical Anatomy
基金
深港创新圈资助计划项目(SG200810200101A)
深圳市科技研发项目(GJHZ20130412153906739
CXZZ20130321152713220)
广东省医学科研基金项目(B2012320)
广东省教育厅育才项目(2012LYM_0120)
关键词
纳米材料
羟基磷灰石
人工骨
骨缺损
Nano-material
Lydroxyapatite
Artificial bone
Bone defect
