血红素加氧酶-1与角膜病、青光眼、白内障及视网膜疾病的关系

Research advances in relationship between HO-1 and corneal diseases,glaucoma,cataract,retinal diseases

血红素加氧酶-1(heme oxygenase-1,HO-1)是体内最重要的内源性抗氧化酶之一。它可以催化血红素分解为一氧化碳、铁离子和胆绿素,HO-1及其产物具有抗氧化、抗炎和抗凋亡等功能。越来越多的研究显示,诱导HO-1表达上调可以保护角膜、小梁网、晶状体及视网膜等眼部组织免受氧化损伤,成为治疗相关眼科疾病的潜在靶点。本文就HO-1在眼科疾病中的最新研究进展作一综述。

Heme oxygenase -1 （ HO-1 ） is one of the most important endogenous an- tioxidant enzymes in body. It can catalyze the degradation of heme to carbon monox- ide, free iron and biliverdin. HO-1 and its products have antioxidant, anti-inflammatory and anti-apoptosis effects. More and more researches have shown that induction of HO- 1 expression can protect cells in cornea, trabecular, lens and retina from oxidative damage, therefore HO-1 has become the potential target for curing disease in such are- as. This article reviews the relationship between HO-1 and eye diseases.