摘要
钙库操纵的钙通道(store operated Ca2+channel,SOCC)和钙库操纵的钙内流(store-operated calcium entry,SOCE)普遍存在于细胞之中,是非兴奋细胞主要的钙内流方式,参与了机体众多的生理过程。许多眼科疾病的发生和发展与SOCE的异常密切相关。本文就近年来对SOCE途径的机制、STIM和Orai不同亚型的结构及在眼科疾病中的作用研究进行了回顾,以期为眼科疾病治疗提供新的思路。
Store operated Ca2＋ channel （SOCC）and store-operated Ca2＋ entry （SOCE） are ubiquitously present in every cell type, which represent a predominant pathway of Ca2 ＋ entry into nonexcitable cells. Nevertheless, the phenomenon of aber- rant expressed SOCE has been observed in a growing number of eye diseases. In this paper, the pathways involved in SOCE, STIM （ stromal interaction molecule） and Oral （calcium release-activated calcium channel protein）in different subtypes are reviewed, further the structure and the role of SOCE in eye diseases are elucidated to provide new ideas approach for eye diseases.
出处
《眼科新进展》
CAS
北大核心
2014年第4期389-393,共5页
Recent Advances in Ophthalmology
基金
国家自然科学基金资助(编号:81072961)
山东省自然科学基金资助(编号:ZR2010HM032)~~
关键词
钙库操纵的钙内流
基质相互作用因子
钙释放激活钙通道蛋白
眼科疾病
store-operated Ca2＋ entry
stromal interacting molecule
calcium re-lease-activated calcium channel protein
eye disease
