鼻咽癌动态增强MRI参数与临床病理特征的关系

Correlation of dynamic contrast-enhanced MRI parameters with clinicopathological features of nasopharyngeal carcinoma

目的探讨鼻咽癌动态增强MRI(DCE-MRI)相关参数与其临床病理特征之间的关系。方法对102例经病理确诊的鼻咽癌初诊患者行DCE-MRI,获取ROI的DCE-MRI参数,观察其曲线特征,并分析DCE-MRI相关参数与临床病理特征的关系。结果不同性别、年龄鼻咽癌患者的曲线最大上升斜率(MS)差异无统计学意义(P均>0.05),而不同T分期、N分期及临床分期MS差异有统计意义(P均<0.05);达峰时间(TTP)、曲线下面积(AUC)差异均无统计学意义(P均>0.05)。结论鼻咽癌DCE-MRI相关参数与病变进展密切相关;DCE-MRI技术对辅助诊断鼻咽癌及准确分期有一定价值。

Objective To explore the correlation of dynamic contrast-enhanced MRI （DCE-MRI） parameters with clinico- pathological features in patients with nasopharyngeal carcinoma. Methods Totally 102 patients with pathologically proved nasopharyngeal carcinoma underwent DCE-MRI scanning, and parameters of ROI were obtained. The relationship between DCE-MRI parameters and clinicopathological features of nasopbaryngeal carcinoma were statistically analyzed. Results The differences of maximum slope （MS） among patients with different genders and ages were not statistically significant （both P〉0. 05）, but were statistically significant among different T-stage, N-stage and clinical stage （all P〈O. 05）. No significant difference of time to peak （TTP） nor area under curve （AUC） was observed among tumors with different clini- copathological features （all P〉0. 05）. Conclusion DCE-MRI parameters of nasopharyngeal carcinoma are correlated with tumor development. DCE-MRI may contribute to auxiliary diagnosis and clinical staging for patients with nasopharyngeal carcinoma.