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抗氨基甲酰蛋白抗体在类风湿关节炎诊断的价值 被引量：2

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摘要 RA是一种常见的高度致残性的自身免疫病,临床特征为慢性侵蚀性关节炎,病理改变为滑膜炎、软骨及骨破坏,最终导致关节畸形及致残.RA患者体内可以检测到多种自身免疫抗体,如抗瓜氨酸化蛋白抗体（ACPA）和RF等.1987年ACR制定的RA分类标准对早期出现的RA敏感度较低,2010年ACR和EULAR共同修定RA分类的新标准中,强调了新型自身免疫抗体在RA诊断、判断预后方面的重要价值,本研究重点对抗氨基甲酰蛋白（carbamylated proteins,carP）抗体在RA的价值做一综述.
作者 罗静 李小峰
机构地区 山西医科大学第二医院风湿免疫科
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2014年第4期280-281,共2页 Chinese Journal of Rheumatology
关键词 蛋白抗体 瓜氨酸化 类风湿关节炎 价值 诊断 自身免疫抗体 RA患者 分类标准
分类号 R593.22 [医药卫生—内科学]
  • 相关文献

参考文献10

  • 1Iaisson S, Pietrement C, Gillery P. Carbamylation-derived produ?cts: bioactive compounds and potential biomarkers in chronic renal failure and atherosclerosis[J]. Clin Chem , 2011, 57: 1499- 1505.
  • 2Wynckel A. Randoux C. Millart H. et al. Kinetics of carhamy?lated haemoglobin in acute renal failure[l]. Nephrol Dial Trans?plant. 2000. 15: 1183-1188.
  • 3Wang Z. Nicholls S]' Rodriguez ER. et al. Protein carhamyla?tion links inflammation. smoking, uremia and atherogenesis[J]. Nat Med , 2007, 13: 1176-1184.
  • 4Mydel P. Wang Z. Brisslert M. et al. Carbamylation-dependent activation of T cells: a novel mechanism in the pathogenesis of autoimmune arthritis[J]. J Immunol , 2010. 184: 6882-6890.
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同被引文献28

  • 1潘正论,张源潮.中国内地人群类风湿关节炎与HLA-DRB1共同表位基因关联性的Meta分析[J].中华风湿病学杂志,2004,8(11):662-668. 被引量：19
  • 2KALLBERG H, PADYUKOV L, PLENGE RM, et al. Gene-gene and gene-environment interactions involving HLA-DRBI, PTPN22, and smoking in two subsets of rheumatoid arthritis [ J ]. Am J Hum Genet, 2007, 80 (5) : 867-875.
  • 3VAN DER HELM-VAN MIL AH, VERPOORT KN, BREEDVELD FC, et al. Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis [ J ]. Arthritis Res Ther, 2005,7 (5) : R949-R958.
  • 4SHI J, KNEVEL R, SUWANNALAI P, et al. Autoantibodies recognizing earbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage [ J ]. Proc Natl Acad Sci USA, 2011, 108 (42) :17372-17377.
  • 5WILLEMZE A, TOES RE, HUIZINGA TW, et al. New biomarkers in rheumatoid arthritis [ J ]. Neth J Med, 2012, 70(9) : 392-399.
  • 6TROUW LA, HUIZINGA TW, TOES RE. Autoimmtmity in rheumatoid arthritis: different antigens-commonprinciples[J]. Ann Rheum Dis, 2013, 72 (Suppl 2) : ii132-ii136.
  • 7JAISSON S, PIETREMENT C, GILLERY P. Carbamylation-derived products: bioaetive compounds and potential biomarkers in chronic renal failure and atheroselerosis[J]. Clin Chem, 2011, 57 ( 11 ) : 1499-1505.
  • 8WYNCKEL A, RANDOUX C, MILLART H, et al. Kinetics of earbamylated haemoglobin in acute renal failure[J]. Nephrol Dial Transplant, 2000, 15 (8): 1183-1188.
  • 9WANG Z, NICHOLLS S J, RODRIGUEZ ER, et al. Protein carbamylation links inflammation, smoking, uremia and atherogenesis [ J]. Nat Med, 2007, 13 (10) : 1176-1184.
  • 10BURSKA AN, HUNT L, BOISSINOT M, et al. Autoantibodies to posttranslational modifications in rheumatoid arthritis [ J ]. Mediators inflamm, 2014, 2014:492873.

引证文献2

中华风湿病学杂志
2014年 第4期

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