eIF3a与肿瘤的研究进展

Research progress on eIF3a and cancer

翻译是细胞中基因表达调控的一个基本步骤,该环节的异常可能会导致肿瘤的发生。在真核生物的细胞内,mRNA的翻译受到许多真核起始因子(eukaryotic initiation factor,eIF)的调控。起始因子eIF3在转录调控,细胞生长和肿瘤的发生中发挥了重要的作用,它的最大的亚基eIF3a可能作为一个mRNA调节器发挥作用。已发现eIF3a与肿瘤的发生相关,并广泛表达于多种肿瘤组织细胞内,调节肿瘤细胞的周期,但对于进展中的肿瘤细胞,eIF3a的表达可能与肿瘤细胞的进展过程负相关;对于化疗药物干预的肿瘤细胞,eIF3a的高表达使肿瘤细胞不易发生耐药,患者的预后更好。关于eIF3a与肿瘤的关系的研究目前还不是很清楚,eIF3a可能参与了肿瘤的病理生理进程,但其发挥的调节作用可能是波动性的。

Translation is a fundamental step in regulation of gene expression and abnormalities in this process may lead to cancer. In eukaryotic cells, translation of mRNA is mainly regulated by many eukaryotic initiation factors （eIFs）. EIF3 plays an impor- tant role in translational regulation, cell growth and oncogenesis. The largest subunit of eIF3, eIF3a may play a role as a regulator of mRNAs. The relationship between eIF3a and oncogenesis has been found. Moreover, the elF3a mRNA is ubiquitously ex- pressed in different cancer cells and can modulate the cell cycle. However, some studies indicate that eIF3a could provide protec- tion against evolution into higher malignancy and reduce the re- sistance to chemotherapy . The patients of high eIF3a expression could get a better prognosis. In fact, the role of eIF3a is still un- clear in cancer cells. EIF3a may be involved in the process of tumor pathophysiology, but its regulatory role is undulatory.