摘要
目的研究阿司匹林对灯盏细辛注射液(DI)中咖啡酸的药代动力学的影响。方法 LC-MS/MS测定大鼠血浆中咖啡酸浓度,实验动物分为对照组和实验组,对照组单独尾静脉给予DI,实验组尾静脉给予DI及灌胃给予阿司匹林。DAS 1.0药动学软件计算药动学参数。结果 DI单独给药、DI-阿司匹林联合给药,咖啡酸在体内代谢动力学模型均为二室开放模型,联合给药后,咖啡酸的T12β明显增大,CL有所减小。结论阿司匹林可减慢咖啡酸在体内的代谢过程。
Aim To investigate the pharmacokinetic effect of aspirin on caffeic acid in dengzhanxixin injec- tion（DI）. Methods Concentration of caffeic acid in rat plasma was detected by LC-MS/MS after rats were given intravenous administration of DI or DI combined with aspirin by gavage. Pharmacokinetic parameters were calculated by DAS 1.0 pharmacokinetie software. Results In vivo pharmacokinetic models of caffeicacid were two-compartment open models in both the caffeic acid group and the caffeic acid combined with aspirin group. After compatibility, caffeic acid showed a significant increase in T1/2β, with a slight decrease in CL. Conclusions Aspirin can reduce metabolic process of caffeic acid in vivo
出处
《中国药理学通报》
CAS
CSCD
北大核心
2014年第4期570-574,共5页
Chinese Pharmacological Bulletin
基金
国家科技部“重大新药创制”科技重大专项(No 2012ZX09303009-002)
江苏省中医药领军人才(No LJ200906)
江苏高校优势学科建设工程资助项目(2010)
