术前肝脏储备功能评估方法的研究进展

Evaluation and development of preoperative liver reserve function evaluation methods

肝切除术是肝脏外科疾病，尤其是肝细胞癌的重要治疗手段。在我国，绝大多数肝癌患者合并有肝硬化等肝实质的广泛性损害，肝脏储备功能有不同程度的降低。肝切除术后肝功能不全甚至肝衰竭成为患者围手术期死亡及影响患者术后长期生存的重要原因。因此，术前精确评估肝脏储备功能十分重要。近年来评估肝脏储备功能的方法越来越多，但是临床上仍然缺少一种公认的、能全面评估肝脏储备功能的方法。通过综述目前临床常用的术前肝脏储备功能的评估方法，总结分析了其中几种重要方法的价值和不足，并对术前肝脏储备功能评估方法的发展进行展望。

[ Abstract] Liver resection is one of the important treat- ments of liver diseases, especially hepatocellular carcinoma. In China, the vast majority of liver cancer patients suffer from generalized damage of the liver parenchyma such as cirrhosis, lead to liver reserve function reducing in various degrees. Liver dysfunction or even liver failure after liver resection becomes an important reason of perioperative death and influences the patients＇ long-term survival. Therefore, accurate preoperative evaluation of liver reserve function is very important. Though there are seveal kinds of assessment of liver reserve function in recent years, it still lack of a clinically recognized, comprehen- sive assessment method. This paper reviewed the clinical com- monly used preoperative liver reserve function evaluation meth- ods, summarizes and analyzes the value and the insufficiency of several important methods, and prospects the development of evaluation methods about preoperative liver reserve function.