抗高血压药物临床应用分析及不良反应预防策略

Clinical application of antihypertensive drugs and prevention strategies for adverse events

目的探讨和分析抗高血压药物临床应用效果及不良反应的预防策略。方法选取我院收治的高血压患者120例,回顾性分析抗高血压药物的临床应用情况及患者出现不良反应的情况。结果四组患者疗效对比分析可知,应用利尿剂治疗的总有效率为90.0%,β受体阻滞剂治疗的总有效率为90.0%,钙拮抗剂治疗的总有效率为87.0%,血管紧张素转换酶抑制剂治疗的总有效率为93.3%,四组患者临床治疗效果均比较显著,组间对比无差异统计学意义(P>0.05)。结论提高对抗高血压药物不良反应的认识,加强抗高血压药物临床应用的规范性和合理性以及标准性,减少用药不良反应的发生率,以此指导患者合理用药,对提高患者生命质量具有极其重要的意义。

Objective To investigate and analyze the clinical application of antihypertensive drugs and prevention strategies for adverse events. Methods A total of 120 hypertensive patients admitted to our hospital were selected. These patients were assigned to diuretic, β-receptor blocker, calcium antagonist, or angiotensin-converting enzyme inhibitor （ACEI）. The clinical application of antihypertensive drugs and incidence of adverse events were retrospectively analyzed. Results The diuretic, β-receptor blocker, calcium antagonist, and ACEI groups had overall response rates of 90.0%, 90.0%, 87.0%, and 93.3%, respectively. The four groups showed significant improvements, but there were no significant differences between groups （P〉0.05）. Conclusion This study improves the understanding of adverse effects of antihypertensive drugs, enhances the standard and proper clinical application of antihypertensive drugs, and reduces the incidence of drug-related adverse events, which provides guidance for rational drug use in patients and is of great significance for improving patients＇ quality of life.