摘要
目的:研究五灵脂的粉体学性质,探讨其粉体学性质与体外溶出行为的相关性。方法:采用振动式低温超微粉碎机对五灵脂进行粉碎,每3 min取样,检测样品粒径、比表面积、孔隙率;以总黄酮含量为指标,考察五灵脂粉体的体外溶出速率,并分析其粉体学性质与体外溶出行为的相关性。结果:随着粉碎时间的增加,粒径逐渐减小,比表面积及体外溶出速率逐渐增加;粉末粒径与体外溶出速率具有良好相关性。五灵脂粉碎时间选择21 min,粒径以d0.9约100μm为宜。结论:五灵脂低温超微粉碎后粒子形态及结构均匀,溶出速率快,有助于后续制剂工艺及质量控制的评价。
Objective:To study powder properties of Faeces Trogopterori and investigate relativity between powder properties and in vitro dissolution behavior.Method:Faeces Trogopterori was crushed by vibration type low temperature ultrafine pulverizer,sampling every 3 min,particle size,specific surface area and porosity of samples were detected ; With the content of total flavonoids as index,in vitro dissolution rate of Faeces Trogopterori powder was investigated,relativity between powder properties and in vitro dissolution behavior was analyzed.Result:With increasing grinding time,particle size decreased,specific surface area and in vitrodissolution rate increased; Powder size and in vitro dissolution rate had a good correlation.Grinding time of Faeces Trogopterori selected 21 min,but particle size of d0.9 should choose was about 100 μm.Conclusion:After low-temperature ultrafine ground of Faeces Trogopterori,particle morphology and structurewas uniform with high dissolution rate,which was helpful forits subsequent evaluation of preparation process and quality control.
出处
《中国实验方剂学杂志》
CAS
北大核心
2014年第8期1-4,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81274098)
关键词
粒径
比表面积
孔隙率
吸附-脱附等温线
溶出速率
五灵脂
粉体学特性
particle size
specific surface area
porosity
adsorption-desorption isotherms
dissolution rate
Faeces Trogopterori
powder properties