正交试验优选无名异的炮制工艺

Optimization of Processing Technology of Pyrolusitum by Orthogonal Design

目的:优选无名异的炮制工艺。方法:以MnO2含量为指标,通过正交试验考察煅制温度、米醋用量、煅制时间对无名异炮制工艺的影响,考察炮制工艺对MnO2含量及药材显微形态的影响。结果:最佳炮制工艺为煅制温度700℃,米醋用量20%,煅制时间40 min;生品和炮制品中MnO2质量分数(x珋±s,n=3)分别为(6.13±0.50)%,(7.35±3.27)%;与生品相比,无名异经煅制醋淬后,在光学显微镜下观察到透明晶体的数量增加,在偏光显微镜下观察到有色晶体的数量增加,晶体的外型均呈块状或肾状。结论:优选的无名异炮制工艺稳定可行,为无名异的炮制工艺规范提供参考。

Objective：To optimize processing technology of pyrolusitum.Method：Taking the content of MnO2 as index,orthogonal test was designed to optimize processing technology of pyrolusitum with processing temperature,the amount of vinegar and processing time as factors.Effects of processing technology on the content of MnO2 and microscopic morphology of pyrolusitum before and after processed were investigated.Result：The best processing technology of pyrolusitum were identified as calcining for forty min under temperature of 700 ℃ with vinegar amount of 20％ ; Under these conditions,the mass fraction of MnO2 in crude and processed products were （6.13 ±0.50）％ and （7.35 ±3.27）％,respectively; Compared with crude products,after vinegar quenched of pyrolusitum,its transparent crystals number increased which could be observed under an optical microscope,appearance of crytals showed a lump or kidney shaped.Conclusion：This optimized technology was stable and feasible,which could provide a reference for criterion of processing technology of pyrolusitum.