疏肝化浊降糖方对2型糖尿病胰岛素敏感性的影响

Influence of Shugan Huazhuo Jiangtang Decoction on Cure of Type 2 Diabetes Mellitus Insulin Sensitivity

目的:观察疏肝化浊降糖方对2型糖尿病(T2 DM)胰岛素敏感性的影响及作用机制。方法:100例T2 DM患者随机按就诊顺序分为对照组和观察组各50例。对照组口服吡格列酮二甲双胍片,1片/次,2次/d。观察组在对照组治疗的基础上加服疏肝化浊降糖方,1剂/d。两组疗程均为12周。测量体重(Wt)、腰围(WC)、空腹血糖(FBG)、空腹胰岛素(FINS)、餐后2 h血糖(2h PBG)及糖化血红蛋白(HbAlc),并计算体重指数(BMI)、胰岛素抵抗指数(HOMA-IR)、胰岛β细胞分泌功能指数和胰岛素敏感指数(ISI);检测血清瘦素(LP)、血清脂联素(APN)、白细胞介素(IL-6)。结果:治疗后观察组FBG,2 hPG,HbA1c及FINS水平低于对照组(P<0.01),观察组BMI,HOMA-IR低于对照组(P<0.01),HOMA-IS和ISI高于对照组(P<0.01),IL-6,LP水平低于对照组(P<0.01),APN高于对照组(P<0.01)。结论:疏肝化浊降糖方能调节糖代谢,降低T2 DM患者血糖,并能改善β细胞分泌功能,提高机体胰岛素敏感性,其作用机制可能与其减轻炎症有关。

Objective：Observe the influence and mechanism of Shugan Huazhuo Jiangtang decoction on type 2 diabetes mellitus （T2 DM） insulin sensitivity.Method：One hundred cases of patients with T2 DM were randomly divided into control group （50 cases） and observation group （50 cases） according to the hospital order.The patients in the control group took pioglitazone metformin tablets,1 piece/time,2 times/day.Patients in observation group took Shugan Huazhuo Jiangtang decoction based on control group＇s treatment,1 does/day.Treatment courses for two groups continued 12 weeks.Measure weight （Wt）,waist circumference （WC）,fasting blood-glucose （FBG）,fasting insulin （FINS）,2 h postprandial blood glucose （2 hPBG） and glycosylated hemoglobin （HbAlc）.Calculate body mass index （BMI）,homeostasis model assessment for insulin resistance （HOMA-IR）,islet B cell secretion index and insulin sensitivity index （ISI）.Detect serum leptin （LP）,adiponectin （APN）,interleukin （IL-6）.Result：After treatment,the level of FBG,2 hPG,HbA1c and FINS of the observation group were lower than that of the control group （P ＜ 0.01）,and the level of BMI and HOMA-IR of the observation group were lower than that of the control group,the level of HOMA-IS and ISI were higher than that of the control group （P ＜ 0.01）,the level of IL-6 and LP were lower than that of the control group,but the level of APN was higher than that of the control group （P ＜ 0.01）.Conclusion：Shugan Huazhuo Jiangtang decoction can regulate glucose metabolism and reduce blood glucose of T2 DM patients,besides,it can also improve secretion function of beta-cell and improve insulin sensibility of bodies,the mode of action may be related to the relief of inflammation.