高血压病中医辨证分型与血浆同型半胱氨酸(HCY)的相关性研究

Study on relationships between TCM syndrome types of hypertension and plasma homocysteine( HCY)

目的:探讨高血压病中医辨证分型与血浆同型半胱氨酸(HCY)的相关性,为高血压病的中医辨证分型提供客观化依据,从而指导临床高血压病的中医辨证施治。方法:对121例高血压病患者进行血浆HCY检测,并依据《中药新药临床研究指导原则》中的标准对每位患者进行中医辨证分型,用SPSS17.0软件进行统计学分析。结果:①与对照组相比,高血压病各中医证型血浆HCY均具有显著统计学意义(P<0.01)。②高血压病痰湿壅盛型血浆HCY与阴阳两虚型的进一步比较具有统计学意义(P<0.05),与肝火亢盛型、阴虚阳亢型的进一步比较具有显著统计学意义(P<0.01),均值比较为:痰湿壅盛型>阴阳两虚型>阴虚阳亢型>肝火亢盛型。结论:①高血压病各中医证型的血浆HCY均伴有不同程度的升高,且具有一定相关性。②痰湿壅盛型的血浆HCY在各中医证型中升高的程度最大,可以将血浆HCY作为高血压病痰湿壅盛证分型的客观指标。

Objective： To explore the relationships between TCM syndrome types of hypertension and plasma homocysteine （HCY） ,so as to provide an objective basis for TCM syndrome types to guide the clinical treatment of hypertension. Methods：Plasma HCY detection of 121 cases of hypertension patients, and on the basis of Guidance Principle of Clinical Study on New Drugs of TCM in the standard for each patient by TCM syndrome types ,was analyzed by SPSS17.0 software. Resuits ：①Compared with the control group, all TCM syndrome types of hypertension with plasma HCY were statistically significant （P 〈0. 01 ）. ②Further comparison of plasma HCY between excessive damp-phlegm type and deficiency of both yin and yang type was statistically significant （ P 〈 0. 05 ）, while further comparison of plasma HCY between excessive damp-phlegm type and hyperactivity of liver-fire type, hyperactivity of yang due to yin deficiency type were statistically significant （P 〈 0.01 ）, and the result of mean comparison of plasma HCY between different types was：excessive dampphlegm type 〉 deficiency of both yin and yang type 〉 hyperactivity of yang due to yin deficiency type 〉 hyperactivity of liver-fire type. Conclusion ：①Plasma HCY in different TCM syndrome types of hypertension were associated with increased in different degree, and has certain relevance. ②Plasma HCY of excessive damp-phlegm type increased largest of degree in all TCM syndrome types, and thus can be considered that plasma HCY can be used as an objective index of excessive damp-phlegm type of hypertension.