单项抗-HBc阳性无症状HBV携带者的肝组织损伤研究

STUDY ON LIVER TISSUE INJURY FROM THE ASYMPTOMATIC HBV CARRIER WITH SOLE POSITIVE ANTI-HBc

目的 :探讨单项抗HBc阳性无症状HBV携带者的肝组织病理改变 ,为临床肝病的防治提供依据。方法 :4 6例单项抗HBc阳性 ,HBVDNA阳性 ,肝功能正常的患者做组织学检查 ,并用免疫组化的方法检测肝组织中HBsAg和HBcAs。结果 :肝组织正常者 8例 (17.39% ) ;轻度慢性肝炎 35例 (76 .0 9% ) ,其中Ⅰ型为 17例 (36 .96 % ) ,Ⅱ型为 18例 (39.19% ) ;中度慢性肝炎 3例 (6 .52 % )。肝组织HBsAg阳性 19例 (41.3% )、HBcAg阳性 13例 (2 8.2 6 % )。结论 :单项抗HBc阳性、HBVDNA阳性患者存在不同程度的肝组织学损伤 ,对此类患者给予动态的医学观察是必要的。

Objective:To study liver tissue injury from the asymptomatic HBV carriers with sole positive anti-HBc, so as to provide scientific basis for prevention and cure of liver disease.Methods:Liver histology was examined and HBsAg、 HBcAg of the liver tissue were tested by immunohistochemical methods from 46 patients with both anti-HBc and HBVDNA positive in the serum.Results:Histological examinaton showed 8(17.39%) patients with normal liver histology; 35(76.09) patients with mild chronic hepatitis,of them, 17(36.96%)patients were classified into I type mild hepatitis and the other 18(39.14%)patients into II type hepatitis; 3(6.52%) patients with moderate chronic hepatitis. In the liver tissue, 19(41.3%)patients were HBsAg positive and 11(23.91%)patients were HBcAg positive.Conclusion:There were different degrees of liver tissue injury in the asymptomatic HBV carriers with sole positive anti-HBc. Dynamic medical observation on these patients is necessary.